Uterine leiomyoma with peculiar skeletal muscle like and rhabdoid cells - case discussion and literature review

Tumors with skeletal differentiation [rhabdomyoma, rhabdomyosarcoma] and extra-renal rhabdoid tumors have been reported in uterus but cases of uterine leiomyoma with skeletal muscle like cells or cells resembling those of extra-renal rhabdoid tumors are rare. We describe clinical and pathological features of one such case of typical uterine leiomyoma in which histopathology showed presence of rounded, polygonal, and strap cells having abundant eosinophilic cytoplasm with round to oval nuclei, some of which were eccentric in position referred to as rhabdoid cells. Intra and extra-cytoplasmic hyaline globules were observed in these cells. However, no cross smooth muscle origin [positive for desmin and h-caldesmon while negative for cytokeratin, myogenin, myoglobin, and myo D1]. We also review the pertinent literature and emphasize that presence of such cells may lead to problems is important so that overtly aggressive management of a benign tumor is avoided

Pilomatrixoma: features of a case diagnosed by fine needle aspiration with literature review

Pilomatrixoma [PMX] is a benign skin appendage tumor with differentiation toward hair cells, particularly hair matrix. It has classic histomorphology. However, fine needle aspiration cytology [FNAC] diagnosis may be extremely dificult and it can be mistaken for a malignant tumor. To our knowledge there are isolated case reports and some handful of series of cases reported in the literature elaborating cytologic features of PMX. We describe clinical and cytological findings in a 29-year-old male patient with skin nodule on the right upper arm. We also review the literature and conclude that identification of unique constellation of cytological features, e.g., basaloid cells, ghost cells, refractile keratin material and foreign body giant cells etc., in appropriate clinical context are most helpful in diagnosis and obviate unnecessary radical surgery

Pneumatosis intestinalis of small bowel in an adult: a case report

Pneumatosis Intestinalis [PI] is rare in adults although it can be seen in the pediatric population as a complication of necrotizing enterocolitis. We report a case of PI affecting the small bowel in a 27-year-old patient who presented with signs and symptoms of acute abdomen due to perforated duodenal ulcer. Histopathologic findings are demonstrated and the pathogenesis is discussed with the objective of highlighting that PI is not a diagnosis but a finding which needs further evaluation and management in view of the underlying etiology