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1.
Artículo | IMSEAR | ID: sea-217331

RESUMEN

Background: Heart rate variability (HRV) is a used to assess autonomic nervous system input to the heart. Studies on the impact of HRV on underweight are limited. Aims/Objectives: To evaluate HRV in age matched young adults of different BMI category. Methodology: This cross-sectional study was done among healthy young adult volunteers between 18 and 25 years of age. Anthropometric variables were measured. ECG was recorded in lead II configuration for 5 minutes. Heart rate variability was analysed with Kubios HRV analyzer. Results: HRV indices were reduced in underweight (UW), overweight (OW) and obese group compared to normal weight (NW) BMI group. Second order polynomial regression between BMI and HF log power in both genders shows an inverted U-shaped relationship with BMI. The association between BMI, waist circumference and body fat (percentage) with HRV indices shows a significant relation to heart rate var-iability among which waist circumference (WC) shows a greater association with HRV indices than BMI. Comparison of HRV parameters among men and women of different BMI group shows female had great-er heart rate variability compared to males across BMI Conclusions: underweight individual also have increased cardiovascular risk like obese group and ab-dominal obesity is better indicator of cardiovascular risk than BMI.

3.
Asian Pacific Journal of Tropical Medicine ; (12): 455-458, 2012.
Artículo en Inglés | WPRIM | ID: wpr-819653

RESUMEN

OBJECTIVE@#To investigate the antioxidant and anti-inflammatory activity of orally administered methanolic leaf extract of Dalbergia paniculata (D. paniculata) in Carrageenan induced inflammation in rats.@*METHODS@#In vitro antioxidant activity was evaluated for superoxide radical, Hydroxyl radical and DPPH radical scavenging activity. Three doses 200 mg/kg, 400 mg/kg and 800 mg/kg of D. paniculata were tested for anti-inflammatory activity in Carrageenan induced rat paw edema model and paw thickness was measured every one hour up to 6 h.@*RESULTS@#The methanolic leaf extract of D. paniculata produced dose dependent inhibition of Superoxide radical, Hydroxyl radical and DPPH radicals. In Carrageenan induced inflammation model, all three doses produced significant percentage inhibition of rat paw edema and 800 mg/kg dose produced maximum percent inhibition of rat paw edema (47.83%) at 3h compared to control group.@*CONCLUSIONS@#In the present study we found that methanolic leaf extract of D. paniculata showed good in vitro antioxidant activity and in vivo anti-inflammatory activity in rats.


Asunto(s)
Animales , Femenino , Masculino , Ratas , Análisis de Varianza , Antiinflamatorios , Farmacología , Carragenina , Toxicidad , Dalbergia , Relación Dosis-Respuesta a Droga , Edema , Quimioterapia , Radical Hidroxilo , Fitoterapia , Métodos , Extractos Vegetales , Farmacología , Hojas de la Planta , Ratas Wistar
4.
Artículo en Inglés | IMSEAR | ID: sea-141377

RESUMEN

Objective To describe the clinical presentation, localization techniques, surgical procedures and outcome in patients with insulinoma. Methods Retrospective analysis of case records of patients diagnosed with insulinoma between January 1993 and June 2009 at a tertiary-care hospital was done. Seventeen patients underwent diagnostic 72-h fast. The sensitivity of computed tomography (CT) of pancreas was judged using intraoperative findings as the gold standard. Results Twenty-six patients (19 women) with mean age 42.2 years (median age 39.5 years) with biochemical/ imaging evidence of insulinoma were included. All patients who underwent 72-h fast developed symptomatic hypoglycemia within 48 h. The sensitivity and positive predictive value (PPV) of CT of pancreas was 68.4% and 92.8%, respectively. Twenty patients underwent surgery, of whom four were operated on without preoperative localization. Four patients had recurrence of symptoms. Of the six patients who were not operated upon, the lesion was localized in four. Conclusion This audit shows that all patients with insulinoma develop hypoglycemia within 48 h of fasting. CT of pancreas localizes the lesion in two thirds of cases and would be a useful initial investigation in patients with suspected insulinoma.

5.
Indian J Pediatr ; 2010 Apr; 77(4): 443-444
Artículo en Inglés | IMSEAR | ID: sea-142556

RESUMEN

We report a case of prepubertal gynecomastia diagnosed during growth hormone (GH) treatment. In our patient gynecomastia appeared 6 months after GH was started. This condition appears to be self-limited and benign. In our patient gynaecomastia resolved on its own.


Asunto(s)
Adolescente , Trastornos del Crecimiento/tratamiento farmacológico , Ginecomastia/inducido químicamente , Hormona de Crecimiento Humana/efectos adversos , Hormona de Crecimiento Humana/deficiencia , Hormona de Crecimiento Humana/uso terapéutico , Humanos , Masculino
6.
Indian J Pediatr ; 2009 Oct; 76(10): 1045-1047
Artículo en Inglés | IMSEAR | ID: sea-142400

RESUMEN

X-linked Adrenoleukodystrophy (ALD) is the most common of the peroxisomal disorder and is associated with functional defect of the very long chain fatty acid (VLCFA) oxidation leading to the accumulation of VLCFA in the white matter and adrenal cortex. Retrospective evaluation of medical records of ALD patients were carried out. In all the 5 patients the duration of the symptoms varied from 1-7 years. Most of them presented with Addisonian crisis (4/5) and hyperpigmentation (5/5), white half of them (3/5) had neurological symptoms. All patients had biochemical evidence of the adrenal insufficiency. All siblings of patients should be screened for the possibility of ALD with VLCFA.


Asunto(s)
Enfermedad de Addison/etiología , Enfermedad de Addison/fisiopatología , Corticoesteroides/uso terapéutico , Hormona Adrenocorticotrópica/sangre , Adrenoleucodistrofia/complicaciones , Adrenoleucodistrofia/diagnóstico , Adrenoleucodistrofia/tratamiento farmacológico , Adrenoleucodistrofia/genética , Análisis Químico de la Sangre , Niño , Preescolar , Ácidos Grasos no Esterificados/metabolismo , Estudios de Seguimiento , Humanos , Masculino , Estudios Retrospectivos , Medición de Riesgo , Muestreo , Índice de Severidad de la Enfermedad , Resultado del Tratamiento
7.
Middle East Journal of Emergency Medicine [The]. 2004; 4 (1): 44-46
en Inglés | IMEMR | ID: emr-67772

RESUMEN

Major vascular injury during lumbar discectomy is a rare complication of one of the commonest surgical procedures performed in the Neurosurgical unit. Its occurrence may be associated with high morbidity and mortality, particularly if it is not diagnosed at an early stage. We illustrate, in our case, the early manifestations of the injury and the associated hypovolemic shock. In addition, we describe the management approach and the mechanism of this injury. Other types of injuries will be referred to during the discussion of this case


Asunto(s)
Humanos , Masculino , Choque Hemorrágico , Ligamentos Longitudinales/lesiones , Microcirugia/efectos adversos , Aorta Abdominal/lesiones
8.
J Postgrad Med ; 1997 Oct-Dec; 43(4): 104-5
Artículo en Inglés | IMSEAR | ID: sea-117038

RESUMEN

This is a report a case with a unilateral single ectopic ureter associated with ipsilateral incomplete duplication of upper third of the ureter, contralateral quadrufid ureter and L3 hemivertebra. These findings provide further evidence of a generalised mesenchymal or epithelial defect, which would explain a defective ureteral bud and metanephric development, besides associated anomalies.


Asunto(s)
Preescolar , Femenino , Humanos , Uréter/anomalías , Incontinencia Urinaria/congénito , Urografía
10.
Artículo en Inglés | IMSEAR | ID: sea-86088

RESUMEN

Opportunistic infections are known to occur with increased frequency in patients with Cushing's syndrome, particularly those due to ectopic ACTH production. This report highlights the rare situation of a patient with Cushing's disease having candidal oesophagitis as one of the major presenting manifestations.


Asunto(s)
Adulto , Candidiasis/complicaciones , Síndrome de Cushing/complicaciones , Esofagitis/microbiología , Humanos , Masculino , Infecciones Oportunistas/complicaciones
12.
Indian Heart J ; 1991 May-Jun; 43(3): 165-70
Artículo en Inglés | IMSEAR | ID: sea-5083

RESUMEN

In 100 patients with unstable angina and 50 patients with stable angina qualitative morphology of coronary artery lesions were compared by angiography. The mean age of the patients was 51 years. In the unstable angina group, 50 patients had rest angina, 32 had crescendo angina and 18 had denovo angina; 31 patients had single vessel disease, 33 had two vessel disease, 34 had triple vessel disease and 2 had left main disease. 'Angina-producing' artery could be identified in 90 out of 100 patients. Ten totally occluded vessels were excluded from analysis. Lesions causing diameter stenosis of greater than 50% could be categorised to one of the following groups: a) Concentric stenosis (18 vessels), b) Type I eccentric lesion (asymmetric narrowing with smooth borders and broad neck--20 vessels), c) Type II eccentric lesion (asymmetric narrowing with narrow neck and overhanging irregular edges--47 vessels), and d) Multiple irregularities (15 vessels). Lesions in 9 vessels showed an associated thrombus. It appears that Type II eccentric lesions are frequent in patients with unstable angina; they probably represent ruptured atherosclerotic plaque or partially occlusive thrombi or both.


Asunto(s)
Adulto , Anciano , Angina Inestable/patología , Angiografía Coronaria , Vasos Coronarios/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Factores de Riesgo
19.
Indian J Chest Dis Allied Sci ; 1978 Jan; 20(1): 28-35
Artículo en Inglés | IMSEAR | ID: sea-30405
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