[Rubella vaccination in pregnancy and serologic situation of infants]

Rubella vaccine is prepared with live virus thus if it injects during abstinence period, it can cause fetal risks. The aim of study was to evaluate rubella IGM among infants of women who were vaccinated against rubella during 3 months pre-or post-conception [abstinence period]. This cohort study was done on 253 mothers, including 116 mothers as cases and 137 mothers as controls. The case group inadvertently had received MR vaccine [RA27/3] during abstinence period. The control group selected randomly from similar delivery center that admitted for delivery. The background and confounding factors was matched between the control and case groups. In both groups after delivery, cord rubella IGM was measured by ELISA for serological diagnosis of infant infection. Data was analyzed by Chi-square and T-student tests. The findings showed that the number of positive IGM infant was similar in both groups [One positive IGM in each group]. In spite of no significant difference between the case and the control groups, the maximum theoretical risk in this study was 4.392% [RR=1.091; 95% CI=0.271-4.392] Although no significant difference was found from the point of infants with an IgM+ serology in two groups, according to the risk ratio obtained in this study, we still recommend vaccination should be avoided during abstinence period

Effect of achiliea santolina on mice spermatogenesis

Achillea santolina, a common variety of Achillea in Golestan province of Iran has been used in traditional medicine for its anti-inflammatory properties. The effect of hydroalcoholic extract [300 mg/kg/day Intraperitoneally, for 20 days] of Achillea santolina on the spermatogenesis of mice was studied by the evaluation of morphologic characteristics by light microscope. The alterations observed were disorganized germ epithelium, exfoliation of immature germ cells, germ cell necrosis and increased number of metaphasfis in germinal epithelium of seminiferous tubules. We concluded that hydroalcoholic extract of Achillea santolina 300mg/kg/day intraperitoneally for 20 days as a different variety of Achillea has antispermatogenic effect similar to Achillea millefolium on mice