Effects cimetidine ranitidine and tiotidine on plasma testosterone and luteinizing hormone level in rats

The investigation was carried out to study the comparative effects of cimetidine, ranitidine and tiotidine on the plasma levels of testosterone and luteinizing hormone under local environmental conditions. The three H2- blocking drugs were injected to the adult male albino rats twice daily at the recommended therapeutic dose levels for six weeks. The data obtained showed that only tiotidine caused a significant [P< 0.05] increase in the level of testosterone. However, all the three drugs caused a significant rise in the levels of luteinizing hormone and maximum with ranitidine