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3.
Artículo en Inglés | IMSEAR | ID: sea-124481

RESUMEN

Xanthogranulomatous cholecystitis (XGC) is a destructive form of chronic cholecystitis. In some patients it coexists with gall bladder carcinoma (GBC) and is often difficult to differentiate between the two. Present study was performed with an aim to identify differentiating features of XGC and those of XGC with associated Gall bladder carcinoma (XGC ass. GBC). A retrospective analysis of prospectively maintained data of 4800 cholecystectomies performed from January 1988 to December 2003 was carried out. On histopathology 453 cholecystectomy specimens revealed XGC. These patients were divided into two groups, those with associated GBC (n=26) and those without GBC (n=427). Clinical, radiological and operative findings were compared in these two groups. P value of < 0.05 was considered statistically significant. The incidence of associated GBC in present series was 6%. XGC patients with associated GBC, at presentation were older than those with XGC alone and there was male preponderance. XGC patients with associated GBC were more likely to present with anorexia, weight loss, palpable lump and jaundice. Gall stones were present in majority of patients in both the groups. GB wall thickening, GB mass, enlarged abdominal lymph nodes may be found on imaging in both the groups but more so in patients with associated GBC. Both preoperative FNAC and peroperative FNAC/imprint cytology failed to reveal the associated GBC with XGC in some patients.


Asunto(s)
Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Carcinoma/complicaciones , Distribución de Chi-Cuadrado , Colangiopancreatografia Retrógrada Endoscópica , Colecistectomía , Colecistitis/complicaciones , Diagnóstico Diferencial , Femenino , Neoplasias de la Vesícula Biliar/complicaciones , Humanos , India , Masculino , Persona de Mediana Edad , Xantomatosis/complicaciones
4.
Artículo en Inglés | IMSEAR | ID: sea-63999

RESUMEN

Cystic mesenteric tumors are rare abdominal neoplasms. We report a 55-year-old man with recurrent benign mesothelioma arising from the left colonic mesentery and extending into the scrotal sac. He recovered well after excision of the abdominal and scrotal mass.


Asunto(s)
Diagnóstico Diferencial , Estudios de Seguimiento , Humanos , Laparotomía/métodos , Masculino , Quiste Mesentérico/patología , Mesotelioma/patología , Persona de Mediana Edad , Neoplasias Peritoneales/patología , Medición de Riesgo , Escroto/patología , Índice de Severidad de la Enfermedad
5.
Indian J Pathol Microbiol ; 2000 Oct; 43(4): 471-4
Artículo en Inglés | IMSEAR | ID: sea-72732

RESUMEN

A 45 year old patient wad admitted with pain abdomen and a palpable mass in the epigastrium of 3 months duration. Endoscopy revealed growth in the stomach and biopsy showed poorly differentiated Carcinoma. Distal radical subtotal gastrectomy was done. Histopathology revealed choriacarcinoma with Syncytiotrophoblastic and cytotrophoblastic and foci of adenocarcinoma. Postoperatively urine and serum had very high levels of beta-human chorionic gonogotrophins (B-HCG). Immunochemistry showed positivity for B-HCG. Clinically and on scan both the testis were normal. Because of its rarity, we are presenting this case with brief review of literature.


Asunto(s)
Adulto , Coriocarcinoma/patología , Gonadotropina Coriónica/sangre , Humanos , Masculino , Neoplasias Gástricas/patología
6.
Indian J Pathol Microbiol ; 1999 Jul; 42(3): 327-32
Artículo en Inglés | IMSEAR | ID: sea-73398

RESUMEN

Between June 1994 and December 1995, one hundred and fifteen tumours and tumour-like lesions of the breast were studied in the Department of Pathology, Kasturba Medical College, Mangalore. Neoplasms constituted 80.9% and tumour like lesions accounted for 19.13%. Among the tumours, 51.6% were benign and 48.4% were malignant. Tumour-like lesions included the entire spectrum of fibrocystic disease. Tumours were common between 2nd and 8th decades while tumour-like lesions were uncommon above 6th decade. Whereas benign tumours exhibited ground substance, collagen and reticulin fibres in varying amounts, tumour-like lesions and carcinoma showed more of collagen fibres and less of ground substance. Elastosis and lymphoplasmacytic infiltrate were prominent features in carcinomas rather than in benign lesions.


Asunto(s)
Adulto , Mama/patología , Neoplasias de la Mama/patología , Carcinoma/patología , Femenino , Enfermedad Fibroquística de la Mama/patología , Humanos , Tumor Filoide/patología , Células del Estroma/patología
7.
Indian J Pathol Microbiol ; 1999 Jul; 42(3): 385-6
Artículo en Inglés | IMSEAR | ID: sea-72957
8.
Indian J Biochem Biophys ; 1998 Jun; 35(3): 148-56
Artículo en Inglés | IMSEAR | ID: sea-26391

RESUMEN

Butyrylcholinesterase (BChE) was purified from monkey serum and the catalytic activities were examined. The enzyme has a molecular mass of approximately equal to 74 kDa as seen by SDS-gel electrophoresis. Monkey serum BChE also exhibits an amine sensitive aryl acylamidase (AAA) and a metallocarboxypeptidase activity. The tyramine activation of the aryl acylamidase activity and the metal chelator inhibition of the peptidase activity were characteristics similar to those of the human enzyme. Studies on 65Zn2+ binding and zinc chelate Sepharose chromatography showed that monkey serum BChE and human serum BChE have similar characteristics. Limited alpha chymotrypsin digestion of monkey serum BChE followed by Sephadex gel chromatography cleaved the enzyme into a 36 kDa fragment exhibiting peptidase activity. However the 20 kDa fragment corresponding to cholinesterase and aryl acylamidase activity was not detectable possibly due to the unstable nature of the fragment. Immunological studies showed that a polyclonal antibody against human serum BChE cross reacted with monkey serum BChE. The identical nature of the catalytic activities of human serum BChE and monkey serum BChE supports the postulate that all three catalytic activities co-exist in the same enzyme. This is the first time that purification and characterisation of the monkey serum BChE which has the highest sequence identity and immunological identity with that of human serum BChE, is being reported.


Asunto(s)
Amidohidrolasas/metabolismo , Aminas/farmacología , Animales , Butirilcolinesterasa/sangre , Carboxipeptidasas/metabolismo , Quimotripsina/metabolismo , Encefalina Leucina/metabolismo , Inhibidores Enzimáticos/farmacología , Haplorrinos , Metaloproteínas/metabolismo , Fragmentos de Péptidos/metabolismo , Zinc/metabolismo
10.
Indian Pediatr ; 1986 Apr; 23(4): 307-9
Artículo en Inglés | IMSEAR | ID: sea-13514
11.
Indian J Lepr ; 1985 Oct-Dec; 57(4): 876-8
Artículo en Inglés | IMSEAR | ID: sea-55302

RESUMEN

A rare case of multiple neurofibromatosis (von Recklinghausen's Disease) with bilateral, uniform and gross enlargement of peripheral nerves simulating nerve thickening in leprosy is reported. The case also showed characteristic palmar melanotic macules.


Asunto(s)
Adulto , Diagnóstico Diferencial , Humanos , Lepra/diagnóstico , Masculino , Neurofibromatosis 1/diagnóstico , Nervios Periféricos/patología , Neoplasias del Sistema Nervioso Periférico/diagnóstico , Neoplasias Cutáneas/diagnóstico
14.
J Postgrad Med ; 1980 Oct; 26(4): 257-8
Artículo en Inglés | IMSEAR | ID: sea-116997
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