RESUMEN
A series of 5-benzylidene-3-α-carboxy ethylrhodanine derivatives (3a-m) were synthesized using 3-α-carboxy ethylrhodanine with various substituted aromatic aldehydes in anhydrous sodium acetate in glacial acetic acid by the knoevenagal condensation under microwave irradiation. The compounds synthesized within short time 10-15 min and in good yields. All the compounds characterized by IR, UV, 1H & 13C-NMR and MS spectral data and studied in vitro antibacterial activity.
RESUMEN
The essential oil from the fresh leaves of Chromolaena odorata (Asteraceae) (L.) R.M. King & H. Rob. was obtained by hydro distillation. From the essential oil the compound (I) a triterpene derivative was isolated by column chromatography and it was characterized by IR, 1H-NMR, 13C-NMR and MS spectral data. It was screened for cytotoxicity against HepG2 by MTT assay. It showed significant cytotoxicity with IC50 value of 206.7 μg/ml towards HepG2 cancer cell line.