Peripheral Neurectomy of Infraorbital Nerve -A Treatment Option for Trigeminal Neuralgia: A Case Report.

Trigeminal neuralgia or tic douloureux is a commonly diagnosed facial pain syndrome with a female predominance and with peak occurrence in the age group of above 50 years. Treatment options range from conservative pharmacologic therapy to invasive surgical procedures. The mode of treatment is based on patient’s systemic health, compliance and severity of the disease. Peripheral neurectomy is the safest and simplest method that can be accomplished under local anesthesia with minimum risks and excellent pain relief to the patient. However, there are incidences where this mode of treatment also fails to manage the disease, and further surgical options must be considered. In this case report, we present a case of a 50-year-old female patient who has undergone peripheral neurectomy of infraorbital nerve.

Hyperparathyroidism - Jaw Tumour : A Case Report.

The hyperparathyroidism-jaw tumor (HPT-JT) syndrome is an autosomal dominant disorder characterized by the occurrence of parathyroid tumors and ossifying jaw fibromas. Hyperparathyroidism is due to increased activity of the parathyroid glands, either from an intrinsic abnormal change altering excretion of parathyroid hormone (primary or tertiary hyperparathyroidism) or from an extrinsic abnormal change affecting calcium homoeostasis stimulating production of parathyroid hormone (secondary hyperparathyroidism). Primary hyperparathyroidism is the third most common endocrine disorder, with the highest incidence in postmenopausal women. Here we present an intresting case of hyperparathyroidism– jaw tumour where the patient had reduced serum calcium and serum alkaline phosphate level.

Potassium channel blockade amplifies cardiac instability numerical studies of torsades de pointes.

Suppression of responses to premature stimulation has been the guiding principle in managing many cardiac arrhythmias. Recent clinical trails revealed that sodium channel blockade increased the incidence of re-entrant cardiac arrhythmias resulting in sudden cardiac death, although the physiologic mechanism remains uncertain. Potassium channel blockade offers an alternative mechanism for suppressing responses to premature stimuli. We have developed a simple model of a 2D sheet of excitable cells. We can initiate re-entrant activation with stimuli timed to occur within a period of vulnerability (VP). Reducing the Na conductance increases the VP while reducing the K conductance increases the collective instability of the array, and arrhythmias similar to torsades de pointes seen in patients subjected to K channel blocked can be readily initiated. Thus, while K channel blockade may suppress excitability by prolonging the action potential duration, it appears to simultaneously exhibit proarrhythmic properties that result in complex re-entrant arrhythmias.

A preliminary evaluation of the cases of epstaxis in Zambia

An attempt is made to analyse the epistaxis cases with the routinely available investigations; which seem to be very much promising in arriving at a reasonable diagnosis. In this continent clinicians should also bear sickle-cell disease in mind; while treating the cases epistaxis