RESUMEN
Purpose@#The purpose of this study was to compare the antigenic potency and stability of tetanus and diphtheria (Td) vaccines when combined with aluminum phosphate (AlPO 4) and liposome adjuvants. @*Materials and Methods@#In vitro and in vivo analyses were conducted using the single radial immunodiffusion method and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The Td vaccines were prepared with AlPO 4 adsorption and liposome-mediated delivery, and protein antigens were characterized using these methods. @*Results@#The results revealed that the liposome-mediated Td vaccines exhibited higher immunogenicity compared to the AlP 4-adsorbed Td vaccines. Additionally, the liposome-mediated Td vaccines demonstrated higher stability as native antigens. @*Conclusion@#This study highlights the importance of utilizing liposome adjuvants in vaccine development. The liposome-mediated Td vaccines showed enhanced immunogenicity and stability, making them a promising approach for improving vaccine efficacy. Understanding and optimizing adjuvant strategies can contribute to the development of effective vaccines against various diseases.