Incidence of intussusception in children less than 2 years

Surveillance of baseline incidence of intussusception [IS] in children less than 2 years of age is important for the safety monitoring of second-generation rotavirus vaccines. To estimate the incidence of IS in children aged less than two years, before the implementation of rotavirus vaccination as part of the routine immunization program in Bahrain. Salmaniya Medical Complex [SMC], Kingdom of Bahrain. Retrospective Study. Children aged <2 years with definite IS were identified by daily reviews of the medical records at Salmaniya Medical Complex. The annual incidence of IS was calculated for children aged <1 year and 1-2 years, using the number of subjects with definite IS residing in the study area as numerator and the study area population aged <1 year and 1-2 years, respectively, as the denominator. Twenty-one children, 10 males and 11 females, were diagnosed with definite IS [2004-2006]. The incidence of IS ranged from 35.4-56.3 per 100,000 children aged <1 year and from 6.7-21.7 per 100,000 in children aged 1-2 years [overall 23.4-39.2 per 100,000 children aged <2 years]. Sixteen [76.2%] IS cases occurred in children aged <1 year; incidence peaked between 5-8 months of age. IS cases demonstrated no seasonality. Twenty [95.2%] children had abdominal pain and 17 [81%] had vomiting. No deaths were reported. Incidence of IS in Bahrain reveals a decreasing trend from 2004 to 2006. The incidence was high in the first year of life. These baseline data on IS incidence will facilitate the risk/benefit assessment of rotavirus vaccination once it is routinely used for immunizing infants in Bahrain

Incidence of intussusceptions: five-year hospital-based retrospective review

The aim of this study was to survey the baseline occurrence of intussusceptions [IS] among children less than five years of age who were hospitalized prior to the introduction of the new rotavirus vaccines. Retrospective cohort study. Salmaniya Meical Compelx, Ministry of Health. Intussusception cases in children less than five years, who were admitted to hospital from January 1999 to December 2003 were reviewed. The intussusceptions definition of Brighton Collaboration Working Group was adopted. The incidence of definite Intussusceptions per year was computed. Sixty-six cases were identified, 12 cases were excluded because the date of hospital admission was before the study period. Fifty-four cases fit the criteria and the period of the study. The mean age of the subjects was 9.4 months. Thirty-four [63%] of the subjects were males. The incidence of definite intussusceptions was 17.8 per 100,00 per year in children less than five years of age, and was 72.4 per 100,00 per year in children less than one year of age. Intussusception was high, forty-four [81.5%], in the 211-monhts age group. Intussusception occurred all year round, with no clear seasonal variation. There were no deaths and all subjects who participated in this study had recovered. This study provides, for the first time, a baseline estimate for the incidence rate of intussusceptions in the Kingdom of Bahrain