RESUMEN
Se hizo un ensayo clinicoterapéutico en 60 pacientes atendidos en la consulta de Dermatología del Hospital Provincial Docente Dr Joaquín Castillo Duany de Santiago de Cuba, durante el 2008, con el fin evaluar la efectividad de la pomada de urea en las verrugas plantares. Se conformaron 2 grupos (de estudio y control): los primeros recibieron pomada de urea al 20 por ciento y los segundos pomada salicílica al 40 por ciento. La pomada de urea resultó más eficaz para eliminar las manifestaciones clínicas de esa lesión, en un período de 6 a 8 semanas y no hubo reacciones adversas.
A clinical therapeutical trial was made in 60 patients assisted at the Dermatology department of Dr Joaquín Castillo Duany Teaching Provincial Hospital from Santiago de Cuba, during 2008, aimed at evaluating the effectiveness of the urea ointment in the feet warts. They conformed to 2 groups (study and control): the first group received urea ointment at 20 percent and the second one salicylic ointment at 40 percent. The urea ointment was more effective to eliminate the clinical manifestations of that lesion, in a period of 6 to 8 weeks and there were not adverse reactions.
Asunto(s)
Humanos , Masculino , Adulto , Femenino , Ácido Salicílico/uso terapéutico , Fármacos Dermatológicos/uso terapéutico , Química Farmacéutica , Enfermedades Cutáneas Virales/tratamiento farmacológico , Pomadas/uso terapéutico , Urea/uso terapéutico , Verrugas/tratamiento farmacológicoRESUMEN
Asthma results from allergen-driven intrapulmonary Th2 response, and is characterized by intermittent airway obstruction, airway hyperreactivity (AHR), and airway inflammation. Accumulating evidence indicates that inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (NO). It has been shown that exhaled NO may be derived from constitutive NO synthase (NOS) such as endothelial (NOS 3) and neural (NOS 1) in normal airways, while increased levels of NO in asthma appear to be derived from inducible NOS2 expressed in the inflamed airways. Nevertheless, the functional role of NO and NOS isoforms in the regulation of AHR and airway inflammation in human or experimental models of asthma is still highly controversial. In the present commentary we will discuss the role of lipopolysaccharides contamination of allergens as key element in the controversy related to the regulation of NOS2 activity in experimental asthma.