Combined Delivery of Two Different Bioactive Factors Incorporated in Hydroxyapatite Microcarrier for Bone Regeneration

BACKGROUND@#The delivery of growth factors using a carrier system presents a promising and innovative tool in tissue engineering and dentistry today. Two of the foremost bioactive factors, bone morphogenetic protein-2 and vascular endothelial growth factor (VEGF), are widely applied using a ceramic scaffold. The aim of this study was to determine the use of hydroxyapatite microcarrier (MC) for dual delivery of osteogenic and angiogenic factors to accelerate hard tissue regeneration during the regenerative process. @*METHODS@#Two MCs of different sizes were fabricated by emulsification of gelatin and alpha-tricalcium phosphate (a-TCP).The experimental group was divided based on the combination of MC size and growth factors. For investigating the in vitro properties, rat mesenchymal stem cells (rMSCs) were harvested from bone marrow of the femur and tibia. For in vivo experiments, MC with/without growth factors was applied into the standardized, 5-mm diameter defects, which were made bilaterally on the parietal bone of the rat. The animals were allowed to heal for 8 weeks, and samples were harvested and analyzed by microcomputed tomography and histology. @*RESULTS@#Improved proliferation of rat mesenchymal stem cells was observed with VEGF loaded MC. For osteogenic differentiation, dual growth factors delivered by MC showed higher osteogenic gene expression, alkaline phosphatse production and calcium deposition. The in vivo results revealed statistically significant increase in new bone formationwhen dual growth factors were delivered by MC. Dual growth factors administered on a calcium phosphate matrix showed significantly enhanced osteogenic potential. @*CONCLUSION@#We propose this system has potential clinical utility in providing solutions for craniofacial bone defects, with the added benefit of early availability.

Combined Delivery of Two Different Bioactive Factors Incorporated in Hydroxyapatite Microcarrier for Bone Regeneration

BACKGROUND@#The delivery of growth factors using a carrier system presents a promising and innovative tool in tissue engineering and dentistry today. Two of the foremost bioactive factors, bone morphogenetic protein-2 and vascular endothelial growth factor (VEGF), are widely applied using a ceramic scaffold. The aim of this study was to determine the use of hydroxyapatite microcarrier (MC) for dual delivery of osteogenic and angiogenic factors to accelerate hard tissue regeneration during the regenerative process. @*METHODS@#Two MCs of different sizes were fabricated by emulsification of gelatin and alpha-tricalcium phosphate (a-TCP).The experimental group was divided based on the combination of MC size and growth factors. For investigating the in vitro properties, rat mesenchymal stem cells (rMSCs) were harvested from bone marrow of the femur and tibia. For in vivo experiments, MC with/without growth factors was applied into the standardized, 5-mm diameter defects, which were made bilaterally on the parietal bone of the rat. The animals were allowed to heal for 8 weeks, and samples were harvested and analyzed by microcomputed tomography and histology. @*RESULTS@#Improved proliferation of rat mesenchymal stem cells was observed with VEGF loaded MC. For osteogenic differentiation, dual growth factors delivered by MC showed higher osteogenic gene expression, alkaline phosphatse production and calcium deposition. The in vivo results revealed statistically significant increase in new bone formationwhen dual growth factors were delivered by MC. Dual growth factors administered on a calcium phosphate matrix showed significantly enhanced osteogenic potential. @*CONCLUSION@#We propose this system has potential clinical utility in providing solutions for craniofacial bone defects, with the added benefit of early availability.

CCL2 Chemokine as a Potential Biomarker for Prostate Cancer: A Pilot Study / Journal of the Korean Cancer Association, 대한암학회지

PURPOSE: Prostate specific antigen is not reliable in diagnosing prostate cancer (PCa), making the identification of novel, precise diagnostic biomarkers important. Since chemokines are associated with more aggressive disease and poor prognosis in diverse malignancies, we aimed to investigate the diagnostic relevance of chemokines in PCa. MATERIALS AND METHODS: Preoperative and early postoperative serum samples were obtained from 39 consecutive PCa patients undergoing radical prostatectomy. Serum from 15 healthy volunteers served as controls. Concentrations of CXCL12, CXCL13, CX3CL1, CCL2, CCL5, and CCL20 were measured in serum by Luminex. The expression activity of CXCR3, CXCR4, CXCR5, CXCR7, CXCL12, CXCL13, CX3CR1, CXCL1, CCR2, CCR5, CCR6, CCR7, CCL2, and CCL5 mRNA was assessed in tumor and adjacent normal tissue of prostatectomy specimens by quantitative real-time polymerase chain reaction. The associations of these chemokines with clinical and histological parameters were tested. RESULTS: The gene expression activity of CCL2 and CCR6 was significantly higher in tumor tissue compared to adjacent normal tissue. CCL2 was also significantly higher in the blood samples of PCa patients, compared to controls. CCL5, CCL20, and CX3CL1 were lower in patient serum, compared to controls. CCR2 tissue mRNA was negatively correlated with the Gleason score and grading. CONCLUSION: Chemokines are significantly modified during tumorigenesis of PCa, and CCL2 is a promising diagnostic biomarker.

Realidad de médicos especialistas en el sistema público no municipalizado: Chile 2012 / Reality of medical specialties in the Chilean public health system, not municipalized (2012)

En los últimos años, en el país se ha observado una falencia de médicos especialistas en el sistema público de salud no municipalizado. Probablemente ello se ha debido a una lenta formación de especialistas por las universidades, a una reducción del número de cargos en relación a la demanda y a un éxodo de especialistas hacia el área privada. El objetivo del trabajo, es analizar el número y características de los médicos especialistas registrado en un corte en el año 2012, en base a los datos suministrados por el Ministerio de Salud, CONACEM, Universidades Nacionales y Superintendencia de Salud. Se comprobó un aumento significativo del total de especialistas en el país al comparar las cifras con las correspondientes al año 2004, en el que tenemos también registros confiables, especialmente a las correspondientes al sistema público, que creció al doble. De igual manera observamos crecimiento significativo de los especialistas en Medicina Interna, Cirugía General y Psiquiatría en las Especialidades básicas y de Anestesiología, Traumatología y Ortopedia, Radiología y Oftalmología en las especialidades primarias. Sin embargo, la distribución regional sigue mostrando brechas de atención, especialmente en las zonas de menor población. El incremento de especialistas se ha debido a las medidas adoptadas en conjunto por el Ministerio de Salud y las Universidades, en base a comisiones de estudio y becas de formación. Dado el crecimiento socio-económico y cultural del país proyectado para el 2020/2030, parece necesario mantener un ritmo adecuado de crecimiento de especialistas, merced a la acción mancomunada de las instituciones comprometidas, incluyendo a la función catalizadora del Colegio Médico, en representación de los profesionales en formación.

In the last years, in the country has been observed a deficit of medical specialists in the Chilean public system of health, not municipalized. Probably this deficit is due to the slow formation of specialists from the universities, to a reduction of the “post offers”, in relation to the demand and to a specialists’ exodus towards the private area. The aim of this study, is to analyze the number and main characteristics of medical specialists registered in a period of the year 2012, according the existing dates of Ministry of Health, (*) CONACEM, the National Universities and the Superintendence of Health. It was observed a significant increase of the number of specialists in this year in comparison to the registered data on 2004, mainly oriented to the public sector, which grew doubly, according to reliable sources. Similarly we see significant growth in the specialists in Internal Medicine, General Surgery and Psychiatry in the basic skills and anesthesiology, Traumatology and orthopedics, radiology, and Ophthalmology in the primary specialty. Nevertheless, the regional distribution continues showing deficit of attention, especially in the zones with minor population. The increase number of specialists has been due to joined efforts of Universities and Health Ministry, based in financial support and qualifications studies. According to standard socioeconomic and human development of the country, the goals of WHO (World Health Organization), must be achieved by coordinated efforts of national institutions: Ministry of Health, Universities and Medical College.

Formación de médicos especialistas en el Sistema de Servicios de Salud de Chile: Su evolución en el período 2007-2010 / Training of specialists in the Chilean national health services

Several institutions, such as the Ministry of Health, Universities, the Chilean Medical Association, Scientific societies and public opinion, recognize that there is a deficiency of specialized physicians in Chile. To overcome this shortage of specialists, the Ministry of Health, along with universities, is developing diverse initiatives to train specialists and cope with the requirements of the country. Seventy five percent of posts offered were filled by physicians. The number of positions increased from 173 in 2007 to 576 in 2010, with a cumulative total of 1582 physicians in four years. Fifty two percent are being trained in Basic Primary Specialties and 48 percent in primary specialties. Thirty three percent of graduates have the obligation to continue working in the public service during a certain lapse. This figure will increase to 50 percent in the following years. These specialists are mainly working in the more densely populated regions of the country. The universities that offer the higher number of training positions are the University of Chile, The Catholic University of Chile and the University of Santiago.

Diagnóstico y manejo de la neurocisticercosis en el Perú / Neurocysticercosis diagnosis and management in Peru

La neurocisticercosis (NCC) es la parasitosis humana más frecuente del sistema nervioso central y es causada por las larvas del céstodo Taenia solium. La NCC es endémica en prácticamente todos los paises en vías de desarrollo. En general se presenta como formas intraparenquimales asociadas con convulsiones o formas extraparenquimales asociadas con hipertensión endocraneana. La sospecha clínica y epidemiológica es importante pero el diagnóstico se realiza primariamente por imágenes y se confirma con serología. La tomografía axial computarizada y la resonancia magnética son las pruebas imagenológicas usadas. Como prueba confirmatoria se usa el diagnóstico inmunológico a través de western blot, que actualmente se pude realizar en el Instituto Nacional de Ciencias Neurológicas tanto en suero como en líquido cefalorraquídeo. El tratamiento involucra medidas sintomáticas (control de convulsiones o hipertensión endocraneana según sea el caso) y tratamiento antiparasitario (albendazol o praziquantel). El tratamiento antiparasitario debe hacerse bajo condiciones de hospitalización y en hospitales de tercer nivel.

Neurocysticercosis (NCC) is the most common parasitic disease of the central nervous system and is caused by larvae of the tapeworn Taenia solium. NCC is endemic in almost all developing countries. It presents as intraparenchymal forms associated with seizures or as extraparenchymal forms associated with intracranial hypertension. The clinical and epidemiological suspicion are important but the diagnosis is made primarily by images and confirmed by serology. Computed tomography (CT) and magnetic resonance imaging tests are used. Inmunodiagnosis by Western Blot, which is currently perform in the Instituto Nacional de Ciencias Neurológicas in serum and cerebrospinal fluid serves as confirmatory test. Treatment involves symptomatic measures (control of seizures or intracranial hypertension) and anticysticercal medications (albendazole and praziquantel). Anticysticercal treatment should be used under hospital conditions because of secondary effects.

La hipertensión arterial, ¿Sólo un biomarcador de la enfermedad ateroesclerótica sistémica? / Hypertension as a biological marker of systemic atherosclerotic disease

There is a close link between hypertension and atherosderosis. Hypertension causes atherosclerotic damage of several organs, called target organs and the risk factors for hypertension and atherosderosis are very similar. The risk of mortality associated to hypertension increases with blood pressure values below the cutoff point of normality (140/90 mm Hg), even below 130/85 mm Hg, and includes a stage called pre hypertension. Moreover, the initial damage of the arterial walls and target organs are present before there is a significant elevation of blood pressure. Therefore, hypertension could become a biological marker of the evolution of an underlying atherosclerotic process. A new pathophysiological paradigm has been proposed in which the severity of hypertension is not classified according to blood pressure values, but rather on the initiation and progression of vascular damage among target organs. These alterations determine the prognosis and management of systemic vascular damage that can be called "hypertensive atherosclerotic disease" or simply systemic atherosclerotic disease.

Evolución de la oferta de médicos. Chile 1993-2008 / Evolution of the availability of physicians in Chile

There is a significant increase in the physician availability in Chile in the last 15 years, due to the immigration of foreign physicians, but mainly due to the increasing number of graduates from private universities with medical schools. In the last four years, the number of physicians increased from 25.542 to 29.996 and the number of graduates, from 918 to 1.136. These figures show a nearly exponential growth. The number of physicians/number of beneficiaries' ratio increased from 1/630 to 1/569 in the last four years, due to the greater increase in the number of physicians than in the number of inhabitants. The future will show a similar trend in this ratio. The specialist/general practitioner ratio remains practically the same, as the number of physicians/beneficiaries ratio in the public system. The oversupply of physicians should alert authorities about the inconvenience in creating new medical schools and a careful plan of relationship between the offer and demand of medical services.

Daño cardiovascular por material particulado del aire. Puesta al día 2008 / Association between air pollution and cardiovascular risk

A clear cut relationship between particulate matter air contamination and the mortality and morbidity due to respiratory disease has been observed in the last decades. However there is also a relationship between air pollution and cardiovascular diseases. In big cities, a big or small particle concentration increase of 10 ¡xg/m³ is associated with a significantly higher risk of ischemic heart disease and myocardial infarction, both when acute or chronic exposures are considered. The risk is higher for small particles. Similar risk increases are observed in patients with hypertension, stroke or severe arrhythmias. This association is independent of environmental distracters such as weather, temperature or humidity and of classical cardiovascular risk factors such as age, diabetes, dyslipidemia and obesity. Physicians should be aware of the problem and explain their patients the increased risk that they are facing due to air pollution (Rev Méd Chile 2009; 137: 1217-24).

Actualización de las recomendaciones sobre el uso de la monitorización ambulatoria de presión arterial. Documento de consenso de la Sociedad Chilena de Hipertensión / Update of consensus reccomendations of the Chilean Hypertension Society about ambulatory blood pressure monitoring

Ambulatory blood pressure monitoring (ABPM) is a valuable tool to evaluate the blood pressure pattern, to identify hypertensive patients, to diagnose white coat and masked hypertension and in situations in which a tight control of hypertension is crucial. This is an update of 1999 consensus recommendations about the use to ABPM, considering that there is new evidence concerning its benefits, and the clinical experience with its application has increased. Equipment programming, its installation, the interpretation and analysis of the data are described, and a report sheet for patients is included. New recommendations have been added to the accepted indications. Normal blood pressure ranges for children and pregnant women have been replaced by new data (Rev Méd Chile 2009; 137:1235-47).

Aumento del riesgo de consultas cardiovasculares por contaminación atmosférica por partículas: estudio en la ciudad de Santiago / Increased risk of consultation for cardiovascular problems related to particle atmospheric pollution: a study in Santiago, Chile

Introducción: En la literatura se reconoce que la contaminación del aire por partículas en diversas ciudades determina un exceso del riesgo de enfermedades cardiovasculares. Santiago es una de las urbes con mayor polución de partículas MP 10 y MP 2,5 en el mundo. Objetivo: Estudiar la asociación entre la concentración diaria de partículas y la morbilidad cardiovascular en los 6 Servicios de Urgencia de la ciudad. Métodos: Se consideraron el número total de consultas cardiovasculares en el año 2007, el Infarto miocárdico, accidente cerebro-vascular y crisis hipertensiva. La concentración de partículas se obtuvo de los registros de 7 centros de la red de Monitoreo de la Calidad del Aire de la Región Metropolitana (MACAM) y lasvariables temperatura y humedad, del Instituto de Meteorología de Chile. Estadísticamente se implementó un modelo de regresión múltiple GAM. Resultados: Se observó que para todo el año 2007 las concentraciones de partículas ambientales MP 10 estuvieron altas, sobre la norma recomendada por la OMS. Ello se asoció a un incrementó del 10% del riesgo de consultas cardiovasculares durante todo el año 2007. Para las partículas MP 2,5 el riesgo aumentó en un 17 por ciento. En los meses invernales Junio y Julio, el riesgo aumentó en 15 por ciento y 28 por ciento respectivamente. Todas las cifras resultaron altamente significativas (p< 0.001). Para la crisis hipertensiva, los aumentos del riesgo fueron 4 y 13 por ciento, también significativos. Conclusión: Se concluye que la contaminación por partículas se asocia significativamente a un mayor riesgo de consultas por enfermedades cardiovasculares en la ciudad de Santiago y que el riesgo es mayor en presencia de partículas MP 2,5.

Background: Atmospheric contamination due to particles is recognized as a factor related to an increased risk of cardiovascular disease. Santiago has one of the greatest concentrations of MP 10 and MP 2.5 particles in the world.Aim: to determine the association of daily changes in particle concentration and cardiovascular morbidity in 6 emergency consultation centers in Santiago. Methods: Total number of consults, myocardial infarction, stroke and hypertensive crisis were included as endpoints. Concentration of particles was obtained from registries routinely made in 7 centers of a city based environmental agency (“Monitoring quality of air in the Metropolitan Region”, MACAM). Air temperature and humidity were obtained from the Chilean Meteorology Institute. Data were analyzed using a multiple regression model (GAM). Results: Throughout 2007, concentration of MP 10 was above the norm recommended by WHO. This was associated to a 10 percent increase in CV related consultations. In relation to MP 2.5 the risk was increased 17 percent. The CV risk peaked at 15 percent and 28 percent in June and July, respectively. All relations were highly significant (p<0.001) including the 4 and 13 percent increase in hypertension emergencies. Conclusion: Increased particle concentration in the air is significantly associated to a higher risk of cardiovascular consultation in Santiago. The risk is higher in relation to increased MP 2.5 particle concentration.

Las nuevas escuelas de medicina en el panorama médico actual / The new medical schools in Chile and their influence on the medical scenario

There is concern about the possible consequences caused by the proliferation of private Medical Schools in Chile. Most of these schools have consolidated as health professional training centers, but its presence is changing the scenario of public health and medical profession. The most important consequence is the increase in the number of physicians that will occur, that may exceed the demand of the Chilean population and generate medical unemployment or emigration. There is also concern about the quality of the training process and the preparation and experience of teachers, that derives in the need for accreditation of medical schools. Private Universities are aware of these problems and are working on them. The struggle for clinical fields in the Public Health System has been regulated by an administrative norm of the Ministry of Health.

Evaluación de la toxicidad del extracto acuoso de las hojas de yacón (Smallanthus sonchifolius) administrado por vía oral en ratas / Evaluation of the subchronic toxicity of oral admnistration of aqueous extract of yacon leaves (Smallanthus sonchifolium) in rats

El Smallanthus sonchifolius, oriundo de los Andes y llamado vulgarmente yacón, es conocido por su uso como normoglicemiante e hipolipemiante así como por su utilidad como antioxidante. En la presente investigación evaluamos la toxicidad subcrónica del extracto acuoso de sus hojas, luego de su administración oral en ratas albinas Holtzman. Objetivo: Evaluar la toxicidad del extracto acuoso de las hojas de yacón en ratas albinas sanas. Material y método: Se realizó un estudio experimental en 40 ratas Holtzman, distribuidas en dos grupos (hembras y machos), a las cuales se administró, por vía oral, durante 90 días, dosis de 100, 200 y 500 mg/Kg/día, del extracto acuoso de hojas de yacón. Se tomaron muestras de sangre del plexo orbital del ojo a los 0, 45 y 90 días para llevar a cabo análisis bioquímicos y hermatológicos. Se realizaron, además exámenes histopatológicos de cerebro, hígado y riñones. Resultados: No se encontraron variaciones significativas en ninguno de los exámenes en comparación con las ratas controles (p ø 0.05). Conclusión: El consumo del extracto de hojas de yacón, durante 90 días, no produjo signos de toxicidad en los órganos estudiados.

The Smallanthus sonchifolius, vulgarly known as yacon, an Ades's species is well known for its use as by it's normoglycemic, hipolipemic and antioxidant effects. There are only few studies on this plant. At present we have investigations about it's chemical composition, harverts process, and medical use. In this paper we evaluated the toxicity of the aqueous extract of the organic leaves of Smallanthus sonchifolius on Holtzman albin rats subcronic oral administration of the extract during 90 days. Objective: To evaluate the subchronic toxicity of aqueous extract of the yacon leaves on healthy albina rats. Material and method: An experimental study has been performed on 40 Holtzman rats. Male a female rats were grouped separately. They received oral daily doses of 100, 200 y 500 mg/Kg/ yaconÆs leaves aqueous extract. Blood samples were taken from the rat orbital plexus of the rats at 0,45 and 90 days of treatment for biochemical and haematologic analysis. Histological examination of brain, liver and kigneys was also done. Results: Non significant differences were found in the examinations of the three groups in comparison with control (p ø 0.05). Conclusion: The Smallanthus sonchifolius aqueous extract consumption during 90 days did not produce toxicity signs in the organs studied.

Una mirada crítica en torno al plan AUGE: algunos aspectos generales y valóricos / A critical appraisal to AUGE health plan in Chile

The health reform in Chile established a health plan callee! AUGE that guarantees an access to diagnosis and treatment of certain specifie diseases within a time frame that must be respected. This article reviews and analyzes the general provisions of this plan and its management of values. Aspects that were implemented by the reform are discussed, especially those that refer to direct care of the population. The positive and negative aspects of the reform are balancea and are contrasted with eventual changes that should be made from an ethicalpointofview.

Incorporación de médicos especialistas a la atención primaria ¿una paradoja nacional? / Incorporation ofspecialists to primary health care to increase its efficieney

In the last decade, the number of general practitioners has decreased in Chile and there is a lack ofinterest among new doctors to work in Primary Care. The low number ofpositions for primary care physicians in the national publie and community health services are one cause, among others, for this decrease. On top, there is a lack of incentives and continuous training in community health services. This situation lead to reinforce primary care with internists, gynecologist, surgeons and psychiatrists in training. During their residence, part of the working journey of these trainees will be carried out in general medical outpatients clinics. This solution has been criticized by university authorities. The other solution is to incorpórate certified basic specialists in teams of three to five, in outpatient clinics of communities with high number of beneficiarles. This initiative is supported by the great number of specialists available in Chile, but is hampered by the lack of working positions and financing. It would increase the problem solving capacity at the primary level, decreasing the number of specialist derivations, that collapse secondary levels of health care.

Estado actual de las especialidades médicas en Chile: realidad en el sistema público no municipalizado / Present status of medical specialties in the Chilean public health system

To adequately plan the post graduate training of physicians, we need to know the needs for specialists in the country and the most prevalent diseases and causes of consultations. In 2004, the National System of Health Services assessed the number of hours and types of specialities available, their regional distribution and calculated an approximate number of physicians in charge of those specialities, determining an equivalent per 44 weekly hours of physician. This number of hours is the maximum that a physician is allowed to work per week. Fifty six percent of specialists correspond to basic specialities (3,688 physicians equivalent to 44 hours, 33 percent to primary specialities (2,205 physicians) and 10 percent to subspecialties (666 physicians). The regional distribution of basic specialties is proportional to the population of each region. However, there are gaps in the distribution of primary specialties and subspecialties. The demand for specialists, assessed measuring the yield in minutes of each hired hour, determined that 54 percent of specialist hours are delicated to the new health program that guaranties the access to certain specialties in a predefined lapse, to all beneficiaries (AUGE). Moreover the demand for attentions to cover this health system has a gap of 30 percent in hours or 800 specialists. This motivated the creation of new posts for specialties during 2005 and 2006, equivalent to 250 physicians hired for 44 hours per week.

Sobrevida de la disfunción sistólica severa del ventrículo izquierdo con la terapia farmacológica actual / Survival of patients with severe left ventricular systolic dysfunction under current medication

Antecedentes: La disfunción sistólica severa del ventrículo izquierdo, con su secuela de insuficiencia cardiaca(IC) ha aumentado en las dos últimas décadas, pero su mortalidad ha disminuido con la introducción delos inhibidores de la enzima convertidora y beta-bloqueadores de tercera generación. Objetivo: Evaluar la sobrevida de un grupo de pacientes con IC desde su primera crisis Métodos: Seguimiento de una cohorte de 24 pacientes con IC de diversas etiologías (hipertensiva, alcohólica e idiopática), pero con predominio de arterioesclerosis coronaria (16 pac) durante 11 años. Los pacientes fueron tratados con terapia asociada de enalapril y carvedilol en dosis bajas, además del tratamiento clásico de la IC. Resultados: La mortalidad global fue de 8 pac (33 por ciento) y, expresada en años de seguimiento, fue de 1.8 pac/año. Las crisis de descompensación alcanzaron el 54 por ciento y las hospitalizaciones el 46 por ciento. Conclusiones: En nuestra experiencia, el tratamiento con inhibidores de la enzima convertidora y beta-bloqueadores de tercera generación, asociados a la terapia clásica de la IC, permitió una sobrevida satisfactoria a largo plazo.

Background: Severe left ventricular systolic dysfunction leading to congestive heart failure (CHF) has become more prevalent in the last decades, but mortality from this condition has decreased following the introduction of convertingenzymeinhibitors (ACE) and third generation beta blockers. Aim: To evaluate survival in a group of patients with CHF Methods: Twenty-four patients with congestive heart failure secondary to coronary artery disease (n=16), hypertension, alcoholic or idiopathic cardiomyopathy were followed during 11 years. Patients were treated with combined therapy of enalapril and low dose carvedilol, along with other conventional drugs. Results: Eight patients died during follow up (33 percent or 1.8 patients per year). Decompensation of heart failure occurred in 54 percent and rehospitalization in 46 percent of patients. Conclusion: Treatment with an ACE inhibitor and a third generation beta blocker along with conventional drugs was associated to a satisfactory long term survival in patients with CHF.

Perfil y número de médicos generales que requiere el país / The profile and number of primary care physicians required in Chile

Medical schools curricular planning aim to obtain a physician trained to work as general practitioner and the Chilean health reform, considers ambulatory primary care as the main axis of health care. However there is still a low interest among physicians to work in primary health care, where there are problems related to a low level of clinical resolution, clinical and administrative management deficiencies and a low level of leadership in health promotion. The causes of these deficiencies stem from university training, government policies and the great attraction that exerts the technological and specialized model of secondary and tertiary health care. We analyze the ideal profe that the general practitioner should have in our health care system and the possible solutions to primary health care problems. We also emphasize the need to coordinate the professional resource needs with university training, to reduce the existing gaps between medical training and professional practice.

Exceso de morbilidad respiratoria en niños y adultos mayores en una comuna de Santiago con alta contaminación atmosférica por partículas / Excess respiratory diseases in children and elderly people in a community of Santiago with high particulate air pollution

Background: The relationship between air pollution and health damage has been sufficiently documented. In station "R" of the air quality monitoring system, located in a community of Metropolitan Santiago (Cerro Navia), the Chilean standard of 150 æg/m³, averaged in 24 hours, for particles with a diameter of 10 micrometers or less (PM10), has been exceeded more days than in the rest of the city stations. Aim: To investigate if the population living near that station has a higher proportion of lower respiratory infections than the Metropolitan Region (MR) as a whole. Material and methods: An outpatient clinic located near station "R" (Centro Albertz), was implemented as a sentinel center according to UNICEF methodology, used since 1992 by the Acute Respiratory Infections National Program. Daily information was collected between May and December 2004. Monitoring data included total number of consults by children less than 15 years old for lower respiratory tract infections, pneumonia, obstructive bronchitis syndrome in children and by adults over 64 years old for lower airway disease, chronic obstructive pulmonary disease (COPD), and pneumonia. Results were compared with those of the rest of MR. Results: Compared with the MR, children from the sentinel clinic had a significantly higher proportion of consults for obstructive bronchial syndrome (20.1 percent and 26.4 percent respectively, in p <0.01) and pneumonia (1.3 and 2.7 percent respectively, p <0.01). In the elderly, the average consults for lower airway disease were 17 percent in the sentinel clinic and 12.2 percent in MR (p <0.04). Conclusions: Children and elderly subjects at the sentinel clinic had a significantly higher proportion of respiratory infections (pneumonia and obstructive bronchial syndrome in children and lower airway disease in the elderly) as compared to the Metropolitan Region.