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Objective To observe the curative effect in patients with systemic lupus erythematosus(SLE) complicated by moderate or severe thrombocytopenia with a blood platelet count(BPC) of under 50 × 109/L and analyze its related factors. Methods We retrospectively analyzed the clinical data on 109 SLE patients with mod-erate or severe thrombocytopenia. Results Of the 109 patients,82(75.2%)had complete response(CR),15 (13.8%)had partial response(PR),and 12(11.0%)had no response(NR),respectively. As compared with the CR+PR group,the NR group had a higher incidence rate of decreased bone marrow megakaryocyte(P 0.05 for all comparisons). The total effectiveness rate did not differ signifi-cantly between MP pulse therapy and high-dose corticosteroid therapy. Conclusions A decrease in bone marrow megakaryocytes can be an adverse factorfor affecting the efficacy in patients with SLE complicated by moderate or severe thrombocytopenia.
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Objective:To explore the correlation among hypertension ,hyperlipidemia ,hyperglycemia and body mass index (BMI) in aged people from communities .Methods:A total of 1463 community residents ,who received health exami-nation in our hospital from Jan 2010 to Dec 2012 ,were selected .According to BMI ,they were divided into normal group (n=651) ,overweight group (n=463) and obesity group (n=349) .Blood pressure ,blood glucose and blood lipids were measured and compared among all groups ,and their correlation with BMI were analyzed .Results:Compared with female group ,there were significant rise in detection rates of overweight&obesity (48.77% vs .60.33% ) ,hypertension (14.24%vs .30. 87% ) ,hyperlipidemia (10. 15% vs .30. 63% ) and hyperglycemia (6. 71% vs .12. 32% ) in male group , P<0. 01 all;compared with normal group ,there were significant rise in detection rates of hypertension (16.44% vs .27.43% vs . 33. 24% ) ,hyperlipidemia (9. 37% vs .28. 29% vs .37. 54% ) and hyperglycemia (4. 76% vs .12. 53% vs .16. 33% ) in o-verweight group and obesity group ,P<0.01 all;BMI was positively correlated with levels of blood pressure ,blood glucose and blood lipids (r=0.374 ,0.317 ,0.294 , P<0.01) .Conclusion:Body mass index is significantly positively correlated with hypertension ,hyperlipidemia and hyperglycemia .Body weight control possesses important significance for prevention and treatment of hypertension ,hyperlipidemia and hyperglycemia .