Analysis of 62 adult patients with viral meningitis / 中华实验和临床病毒学杂志

<p><b>OBJECTIVE</b>To investigate the clinical manifestation, cerebrospinal fluid (CSF) and auxiliary examination findings of adult viral meningitis.</p><p><b>METHODS</b>62 adult patients with viral meningitis were retrospectively analyzed.</p><p><b>RESULTS</b>Headache occurred in all the 62 (100%) patients, fever occurred in 61 (98%) patients, meningeal irritation sign occurred in 48 (77%) patients. The abduction of left eye was limited in one patient. Seizure occurred in 2 patients. The mean duration time was 17 days, 93% patients less than 30 days. The pressure of CSF increased in 80% patients, leukocyte counts increased in 91% patients, protein level increased in 81% patients, chloride level was normal in 35% patients and slightly lower in 65% patients, glucose level was normal in 94% patients. 7 patients had positive IgM antibody of Coxackievirus B group both in serum and CSF, one patient had positive IgM antibody of EB virus in CSF. Cranial CT scan had no special findings in all patients. 23 patients performed MRI examination, meningeal enhancement occurred in 9 patients. 52% patients had abnormal EEG, mainly increased local or diffuse slow waves.</p><p><b>CONCLUSION</b>Adult viral meningitis was a kind of self-limited disease, chloride level was slightly lower in more than half patients, meningeal enhancement was detected in MRI in part patients.</p>

Establishment of a model for predicting the postoperative morbidity in patients with pelvic and acetabulum fractures / 南方医科大学学报

<p><b>OBJECTIVE</b>To establish a model for predicting the postoperative morbidity in patients with pelvic and acetabulum fractures.</p><p><b>METHODS</b>The clinical of 94 patients with pelvic and acetabulum fractures were retrospectively reviewed for analysis of the postoperative complications and duration of hospital stay. The preoperative physiological scores (PS) and operative severity scores (OS) of the patients were selected as the variables, and their regression coefficients were calculated by logistic regression analysis to establish the model for predicting the postoperative morbidities. The predictive value of the model was evaluated according to the ROC curve.</p><p><b>RESULTS</b>The model for predicting postoperative morbidities of pelvic and acetabulum fractures, ln P/(1-P)=-13.83+0.47x PS+0.33xOS, has an area under ROC curve of 0.888-/+0.037 with the cut-off point of 37%, sensitivity of 84.21%, specificity of 82.14%, concordance rate of 82.98%, misclassification rate of 15.79% and omission classification rate of 17.86%.</p><p><b>CONCLUSION</b>This model possesses a high predictive capability for postoperative morbidities of pelvic and acetabulum fractures, and can be helpful for clinical therapeutic decision-making and lower the risks in operation.</p>

Effect of cytomegalovirus infection on expression of matrix metalloproteinase-2 in human endothelial cells / 中华实验和临床病毒学杂志

<p><b>OBJECTIVE</b>To investigate the effect of cytomegalovirus infection on expression of matrix metalloproteinase-2 in human endothelial cells.</p><p><b>METHODS</b>Human umbilical vein endothelial cells were cultured in vitro. Cells between 3-6 passages were infected with cytomegalovirus for different time. Expression of matrix metalloproteinase-2 mRNA was analyzed by reverse transcription-polymerase chain reaction, matrix metalloproteinase-2 activity was detected by gel zymography.</p><p><b>RESULTS</b>Expression of matrix metalloproteinase-2 mRNA and its activity 6 hours after infection was almost equal to control, and was greatly enhanced 12 and 24 hours after infection.</p><p><b>CONCLUSION</b>Cytomegalovirus infection up-regulates expression of matrix metalloproteinase-2 in human endothelial cells. It might be one of the mechanisms that cytomegalovirus is involved in atherosclerosis.</p>

Application of skin flaps with supra-carpal cutaneous branch of the ulnar artery and dorsal carpal branch of the anterior interosseous artery in reconstruction of complicated amputaled palm / 南方医科大学学报

<p><b>OBJECTIVE</b>To investigate the clinical efficacy of carpal branch of ulnar artery skin flap and dorsal carpal branch of anterior interosseous artery skin flap in replantation of complicated severed hand.</p><p><b>METHODS</b>From August 1999 to October 2005, 18 patients with complicated severed hands were treated in our department. According to the skin defect of severed hand, the palm of the hand was restored with upper carpal branch of ulnar artery skin flap (2-4 cm x 3-6 cm), followed by restoration of the back of the hand with dorsal carpal branch of anterior interosseous artery skin flap (4-6 cm x 5-8 cm) and replantation of the hand was performed simultaneously.</p><p><b>RESULTS</b>All the replanted hands and the skip flaps survived after the surgery with satisfactory shape and function. The surgery achieved an over 70% recovery of the hand function in all cases.</p><p><b>CONCLUSIONS</b>For complicated severed hands, upper carpal branch of the ulnar artery skin flap and dorsal carpal branch of the anterior interosseous artery skin flap are effective to repair the skin defect, and this procedure provides a good option for reconstructing shape and function of the severed hands.</p>