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1.
International Journal of Oral Science ; (4): 21-21, 2021.
Artículo en Inglés | WPRIM | ID: wpr-888698

RESUMEN

Ossifying fibroma (OF) and fibrous dysplasia (FD) are two fibro-osseous lesions with overlapping clinicopathological features, making diagnosis challenging. In this study, we applied a whole-genome shallow sequencing approach to facilitate differential diagnosis via precise profiling of copy number alterations (CNAs) using minute amounts of DNA extracted from morphologically correlated microdissected tissue samples. Freshly frozen tissue specimens from OF (n = 29) and FD (n = 28) patients were obtained for analysis. Lesion fibrous tissues and surrounding normal tissues were obtained by laser capture microdissection (LCM), with ~30-50 cells (5 000-10 000 µm


Asunto(s)
Humanos , Variaciones en el Número de Copia de ADN , Diagnóstico Diferencial , Fibroma Osificante/genética , Displasia Fibrosa Ósea/genética , Galactosiltransferasas , Maxilares , Recurrencia Local de Neoplasia , Proteínas Nucleares
2.
World Science and Technology-Modernization of Traditional Chinese Medicine ; (12): 1747-1750, 2013.
Artículo en Chino | WPRIM | ID: wpr-439679

RESUMEN

The pathogenesis of irritable bowel syndrome(IBS) has not been fully elucidated. Abnormal gastrointesti-nal dynamics and visceral hypersensitivity were its main pathophysiological basis. Abnormal expression of neu-ropeptides can affect the visceral sensation, secretion and movement, leading to the occurrence of IBS. This article reviewed the relationship between neuropeptides and IBS from the following neuropeptides: 5-hydroxytryptamine (5-HT), corticotropin releasing factor (CRF), vasoactive intestinal peptide (VIP), substance P (SP), and somatostatin (SS). It provided reference evidences for the elucidation of IBS pathogenesis.

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