Correlation Between Peripheral Blood Biomarkers and Efficacy of PD-1/PD-L1 Inhibitors Treatment on Lung Cancer / 肿瘤防治研究

Objective To investigate the predictive and guiding significance of peripheral blood biomarkers on the therapeutic effects of PD-1/PD-L1 inhibitor treatment on lung cancer patients. Methods We collected the data of 200 lung cancer patients treated with PD-1/PD-L1 inhibitors treatment, including clinical indicators, peripheral blood indicators, efficacy indicators and survival indicators. Results The DCR of patients with non-hepatic metastasis, immune combined chemotherapy, NLR≤2.81 and LDH≤202.5 u/L was higher (P < 0.05). The AUC value of NLR combined with LDH predicting DCR was 0.698 (P < 0.05). Univariate analysis showed that non-hepatic metastasis, first-line immunotherapy, immunotherapy combined with chemotherapy and LDH≤202.5 u/L were related to PFS (P < 0.05). Multivariate analysis showed that the patients with non-hepatic metastasis and LDH≤202.5 u/L had longer PFS (P < 0.05). The significant decrease of NLR and LDH after two cycles of immunotherapy indicated the effectiveness of immunotherapy (P < 0.05). Conclusion NLR≤2.81, LDH≤202.5 u/L, non-hepatic metastasis and immunotherapy combined chemotherapy are positively correlated with immunotherapy efficacy. Non-hepatic metastasis and LDH≤202.5 u/L are independent prognostic factors of the patients treated with immunotherapy. The changes of peripheral blood NLR and LDH are related to the efficacy of PD-1/PD-L1 inhibitors treatment.

Oxidative injury on trabecular meshwork / 中华实验眼科杂志

Glaucoma is a group of neurodegenerative disease characterized by progressive retinal ganglion cells (RGCs) death and visual field defect.Although its pathological mechanism is unclear,elevated intraocular pressure is considered to be the main contributing factor.As the main components of the aqueous humor drainage system,the structural abnormalities,dysfunction of trabecular meshwork and Schlemm canals may cause aqueous humor outflow obstruction and result in elevated intraocular pressure.Increasing evidences suggest that oxidative stress is the key factor leading to the apoptosis,dysfunction of the human trabecular meshwork cell,and other progression of degenerative changes.Oxidative damage is an imbalance between the oxidative stress and anti-oxidative system,which leads to lipid peroxidation,protein denaturation and DNA damage.Previous studies showed that the level of oxidative biomarker was elevated in the aqueous humor of glaucoma patients.In addition,oxidative stress is thought contributing to the pathogenesis of DNA damage,mitochondrial dysfunction and inflammation in human trabecular meshwork cells.This review considered the contribution of oxidative stress on human trabecular mesh work dysfunction and its possible mechanisms.