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Chinese Journal of Oncology ; (12): 534-537, 2008.
Artículo en Chino | WPRIM | ID: wpr-357380

RESUMEN

<p><b>OBJECTIVE</b>To investigate the efficacy, safety and the life quality improvement of uroacitides injection in the treatment for patients with advanced malignant tumors.</p><p><b>METHODS</b>A total of 160 patients with advanced stage cancers were enrolled into this multicenter, open and non-randomized phase II clinical trial, including cancers of the lung (33 cases), liver (45 cases), breast (17 cases), esophagus (11 cases), stomach (18 cases), colon (19 cases), pancreas (3 cases) and kidney (4 cases), and glioma (10 cases). Uroacitides was administrated in a dose of 300 ml daily via the superior vena cava catheter for consecutive 4-8 weeks.</p><p><b>RESULTS</b>Of the 160 patients, 21 dropped out and one patient died during the trial. Efficacy could be evaluated in 138 patients and safety in 160. The total objective response rate (ORR, CR + PR)) and tumor control rate (CR + PR + MR + SD) of the 138 evaluable patients were 5.8% and 65.2%, respectively. Clinical benefit response (CBR) rate was 57.2%. Major adverse effects were grade I - II and reversible nausea/vomiting (21.9%) and pain (6.3%).</p><p><b>CONCLUSION</b>Uroacitides injection is effective in the control for various kinds of advanced cancers with mild, reversible and tolerable adverse effects, and can also improve the patient's quality of life. It is worth being studied further.</p>


Asunto(s)
Humanos , Neoplasias de la Mama , Sangre , Quimioterapia , Patología , Antígeno CA-19-9 , Sangre , Antígeno Carcinoembrionario , Sangre , Carcinoma de Pulmón de Células no Pequeñas , Sangre , Quimioterapia , Patología , Cateterismo Venoso Central , Neoplasias Colorrectales , Sangre , Quimioterapia , Patología , Neoplasias Hepáticas , Sangre , Quimioterapia , Patología , Neoplasias Pulmonares , Sangre , Quimioterapia , Patología , Metiltransferasas , Usos Terapéuticos , Náusea , Estadificación de Neoplasias , Péptidos , Usos Terapéuticos , Fenilacetatos , Usos Terapéuticos , Calidad de Vida , Inducción de Remisión , Terapia Recuperativa , Resultado del Tratamiento , Vómitos , alfa-Fetoproteínas , Metabolismo
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