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Objective The aim of our study was to explore the relationship between prostate cancer and four serum markers,including Prostate specific antigen (PSA),Beta 2 Microglobulin (β2M),Neutrophil-to-lympochyte ratio (NLR) and Lactic dehydrogenase (LDH),and their variation rules in development of prostate cancer.Then to find one or more markers that can increase the sensitivity and specificity of diagnosis to provide reference for clinic.Methods A total of 149 prostate cancer patients,40 patients with benign prostatic hyperplasia,80 healthy subjects in our hospital were analyzed,and subsequent the T-PSA,F-PSA,β2M,LDH and NLR were measured.The correlation between these markers and prostate cancer as well as its different types and Gleason score was assessed statistically.We determined the cut-off point of the NLR and T-PSA according to the specificity and sensitivity levels derived from area under receiver operator characteristic (ROC) curve.Results The level of T-PSA was significantly higher in patients of prostate cancer and benign prostatic hyperplasia,and the level of NLR was higher only in patients of prostate cancer.Based on the area under ROC,the cut-off value of T-PSA was determined to be 4.625 ng/ml,and NLR was 2.11,and combined NLR and T-PSA can increase the specificity of diagnose.There is a statistical difference in Gleason scores in patients with different NLR of prostate cancer (P =0.030).Conclusions It could increased the specificity when combined NLR and T-PSA to diagnose prostate cancer.And NLR has positive correlation with the prognosis of patients of prostate cancer as well.
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Objective To investigate the correlation between hope level and self-management behaviors among patients with type 2 diabetes.Method One hundred and ninety-eight hospitalized patients with type 2 diabetes were recruited in the investigation by convenience sampling in a first-class grade I hospital from December 2015 to April 2016 to understand the status of hope and self-management behaviors as well as the correlation between them.Results The score on hope level was (35.0±3.6),which was in a medium or above level.The total score of self-management behaviors was (84.1 ±13.0),which indicated their self-management remained in the middle level.The total score on the hope level and its all dimensions were positively correlated with the total score on self-management behaviors and the dimensions such as drug compliance,foot care,high and low blood sugar processing (all P ＜0.05).There was a positive relationship between maintain close relationship with others and regular exercise (P＜0.05).The average score on hope and each dimension were insignificantly correlated with diet control and blood glucose monitoring (all P＞0.05).Conclusions The hope of 2 diabetic patients is in a medium or above level.The hope level is closely related to their self-management behaviors.The nurses should pay attention to the hope level of patients.Effective nursing interventions should be adopted to improve the self-management ability and quality of life in patients with type 2 diabetes.
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<p><b>OBJECTIVE</b>To report on a Chinese family from Wenzhou with genetically confirmed Kennedy disease and describe its clinical and genetic features.</p><p><b>METHODS</b>The clinical phenotype and the level of relevant biochemical markers were assessed. To determine the number of CAG repeats in the exon 1 of androgen receptor (AR) gene, genomic DNA was extracted from peripheral blood samples of the family members, amplified by PCR and identified by DNA sequencing.</p><p><b>RESULTS</b>The proband showed predominantly proximal limb weakness, fasciculation, muscle atrophy, gynecomastia, sexual dysfunction and increased serum creatine kinase. Myopathy and neuropathy were identified by electromyography. Two other affected males and 2 affected female carriers were identified to carry an expanded CAG repeat in the AR gene. The numbers of CAG repeats were found to be 43 in the proband, 43 and 42 in the other two affected males, one of which had similar clinical symptoms to the proband.</p><p><b>CONCLUSION</b>The family was diagnosed with Kennedy disease by analysis of the AR gene.</p>