Predictive value of consolidation/tumor ratio at different CT thresholds for invasiveness in small lung cancer / 中国医学物理学杂志

Objective To compare the accuracy of consolidation/tumor ratio(CTR)measured at different CT thresholds for the prediction of invasiveness in small lung cancer with diameter≤2 cm using artificial intelligence-assisted measurements,and to explore the CTR thresholds and the corresponding CT thresholds for predicting lung cancer invasiveness.Methods Clinical data from 59 lung cancer patients(78 lung nodules in total)treated at Wuwei Hospital of Traditional Chinese Medicine from January 2021 to May 2023 were collected to analyze the prediction efficacy of CTR on invasiveness in small lung cancer with diameter≤2 cm measured at CT thresholds of-400,-350,-300,-250,-200,-150 HU.ROC curves were plotted to determine the optimal critical value for invasiveness prediction,followed by the corresponding CT threshold.Results The highest diagnostic efficacy for the invasiveness of lung nodules was achieved at a CT threshold of-250 HU,with an area under the curve of 0.931,sensitivity of 77.5％,specificity of 100％,and an optimal CTR threshold of 0.322.Conclusion For small lung cancers with a maximum diameter≤2 cm,CTR measured at a CT threshold of-250 HU can accurately predict lung cancer invasiveness.At CTR>0.322,the nodule is more likely to be microinvasive or invasive adenocarcinoma.

Research advancement of MiR-200 family in non-small cell lung cancer / 中国综合临床

Lung cancer is the morbidity and mortality of malignant diseases in the world.In recent years,with the analysis of miRNA in tumor expression profiles,it is recognized that miRNA indirectly involved in the development of tumor involved in tumor cell proliferation,apoptosis,adhesion,inducing angiogenesis and other important biological activities.The miR-200 star family occurred in the early cancer and subsequent tumor cell metastasis and invasion process both play a key role in regulating the treatment of non-small cell lung cancer which provides a potential research directions.This paper systematically summarized the research results of miR-200 family in the field of non small cell lung cancer in recent years,and discussed the application value in clinical practice.