RESUMEN
In summary the carbon tetrachloride/phenobarbital of cirrhosis in rats mimics human cirrhosis very closely, with development of ascites and SBP. This model shows us that bacterial overgrowth occurs as cirrhosis progresses and that bacterial translocation from the gut to extra-intestinal sites is part of the early pathogenesis of SBP. SID with norfloxacin dramatically reduced translocation and SBP at the expense of grampositive overgrowth and infection with gram-positives and colonization with strange gram negatives. SID with TMP-SMZ actually delayed development of ascites and prolonged survival.
Asunto(s)
Animales , Ratas , Ascitis/microbiología , Cirrosis Hepática Experimental/complicaciones , Peritonitis/microbiología , Traslocación Bacteriana/fisiología , Ascitis/prevención & control , Cirrosis Hepática Experimental/inducido químicamente , Cirrosis Hepática Experimental/microbiología , Combinación Trimetoprim y Sulfametoxazol/uso terapéutico , Fenómenos Fisiológicos Bacterianos , Intoxicación por Tetracloruro de Carbono , Norfloxacino/uso terapéutico , Peritonitis/prevención & control , Profilaxis Antibiótica , Traslocación BacterianaAsunto(s)
Humanos , Cirrosis Hepática/microbiología , Infecciones Bacterianas/complicaciones , Peritonitis/microbiología , Peritonitis/tratamiento farmacológico , Antibacterianos/uso terapéutico , Cefotaxima/uso terapéutico , Ceftriaxona/uso terapéutico , Cirrosis Hepática/complicaciones , Escherichia coli/patogenicidad , Líquido Ascítico/microbiología , Norfloxacino/uso terapéutico , Peritonitis/diagnóstico , PronósticoRESUMEN
Patients with cirrhosis are regularly infected with a plethora of bacteria, fungi and mycobacteria. A high index of suspicion of infection and a low threshold for culturing, ascitic fluid, blood, urine, pleural fluid, spinal fluid, joint fluid, etc will lead to a rapid diagnosis of infection and perhaps prolong survival of these very fragile patients.