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Chinese journal of integrative medicine ; (12): 431-437, 2015.
Artículo en Inglés | WPRIM | ID: wpr-310867

RESUMEN

<p><b>OBJECTIVE</b>To investigate whether emodin exerts protective effects on mouse with allergic asthma.</p><p><b>METHODS</b>A mouse model of allergic airway inflflammation was employed. The C57BL/6 mice sensitized and challenged with ovalbumin (OVA) were intraperitoneally administered 10 or 20 mg/kg emodin for 3 days during OVA challenge. Animals were sacrificed 48 h after the last challenge. Inflammatory cell count in the bronchoalveolar lavage fluid (BALF) was measured. The levels of interleukin (IL)-4, IL-5, IL-13 and eotaxin in BALF and level of immunoglobulin E (IgE) in serum were measured with enzyme-linked immuno sorbent assay kits. The mRNA expressions of IL-4, IL-5, heme oxygenase (HO)-1 and matrix metalloproteinase-9 (MMP-9) were determined by real-time quantitative polymerase chain reaction.</p><p><b>RESULTS</b>Emodin induced significant suppression of the number of OVA-induced total inflammatory cells in BALF. Treatment with emodin led to significant decreases in the levels of IL-4, IL-5, IL-13 and eotaxin in BALF and total IgE level in serum. Histological examination of lung tissue revealed marked attenuation of allergen-induced lung eosinophilic inflammation. Additionally, emodin suppressed IL-4, IL-5 and MMP-9 mRNA expressions and induced HO-1 mRNA expression.</p><p><b>CONCLUSION</b>Emodin exhibits anti-inflammatory activity in the airway inflammation mouse model, supporting its therapeutic potential for the treatment of allergic bronchial asthma.</p>


Asunto(s)
Animales , Femenino , Líquido del Lavado Bronquioalveolar , Biología Celular , Quimiocinas , Metabolismo , Modelos Animales de Enfermedad , Emodina , Química , Farmacología , Usos Terapéuticos , Regulación de la Expresión Génica , Hemo-Oxigenasa 1 , Genética , Metabolismo , Inmunoglobulina E , Sangre , Interleucinas , Genética , Metabolismo , Leucocitos , Metabolismo , Pulmón , Metabolismo , Patología , Metaloproteinasa 9 de la Matriz , Genética , Metabolismo , Ratones Endogámicos C57BL , Ovalbúmina , Neumonía , Sangre , Quimioterapia , Patología , Sustancias Protectoras , Farmacología , Usos Terapéuticos , ARN Mensajero , Genética , Metabolismo
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