RESUMEN
@#To explore the effect of early progressive rehabilitation on cognitive functions in patients with aneurysmal subarachnoid hemorrhage（aSAH）.Methods Patients diagnosed aSAH in the hospital from March 2018 to March 2019 were included. Information of the patients were retrospectively collected including personal data，clinical features，imaging data，rehabilitation treatment，and followed up for 3 months. All subjects were divided into two groups，according to Mini-mental state score（MMSE）. The difference of personal data，clinical features，imaging data，rehabilitation treatment were compared between the two groups. After adjusting the confounding factors，the effect of early progressive rehabilitation on cognitive functions of the two groups were analyzed. Results One hundred and twelve patients with aSAH were enrolled，including 27（24.11%）patients with cognitive impairment （MMSE score≤26，cognitive impairment group） and 85（75.89%） patients with normal cognition （MMSE score 27～30，normal group）. The ratio of patients over 65 years old or with poor-grade aneurysmal subarachnoid hemorrhage （Hunt-Hess、modified Fisher scale） in the cognitive impairment group were higher than that in the normal group（P<0.05）. Compared with those patients who were in the normal group，the proportion of front traffic/front loop artery aneurysm and aneurysm diameter<3 mm were significantly higher in the cognitive impairment group（P<0.05）. Compared with patients who were in the interventional embolization group, people who treated with clipping surgery the risk of developing into cognitive dysfunction were decreased（P<0.05）. At the same time，it could reduce the risk of deep vein thrombosis （DVT），but could not reduce the risk of cerebral vasospasm or hydrocephalus. After adjusting confounding factors，patients who treated with early progressive rehabilitation were in a lower risk of cognitive impairment（OR=3.631，95% CI 1.007～13.085）. Conclusions Early progressive rehabilitation could improve the short-term cognitive function of patients with aSAH.