RESUMEN
Introduction: Tuberculous lymphadenitis is one of the common cause of Paediatric lymphadenopathy in India. This study was aimed to assess the usefulness of Fine needle aspiration cytology of lymph nodes as a diagnostic tool in suspected Tuberculosis and to observe the cyto morphological changes for better understanding of immune response. Material and methods: This was a cross sectional observational study conducted between the year 2016 to 2018 at Melmaruvathur tertiary care hospital. Children up to 14 years with suspected Tuberculosis symptoms and chronic lymphadenopathy irrespective of the sizes of nodes were subjected to Fine needle aspiration cytological study. Cyto smears morphology were observed and analysed. Results: A total of 81 cases were studied and the predominant age group affected were between five to ten years (n=46; 56.8%). 42 patients were female (51.9%) and 39 were male (48. 1%).Most of them had cervical nodes and 44% of nodes were less than 1 cm size. Out of 81 cases, 32 (39.5%) were diagnosed as nonspecific adenitis and 46 cases (56.8%) as granulomatous lymphadenitis. Among the size of the nodes, 57% of small nodes, 65% of medium sized nodes and 100% of large nodes showed granulomatous adenitis. Among sexes, female preponderance (63.1%) for granulomatous adenitis and male predominance (62.5%) for nonspecific adenitis were observed. Conclusion: Fine needle aspiration cytological study of paediatric lymphadenopathy is a useful diagnostic indicator in suspected Tuberculosis even for small size nodes and can be recommended if clinically warranted.
RESUMEN
Introduction: Insulin affects many sites of mammalian lipid metabolism It stimulates synthesis of fatty acid in liver adipose tissue and in the intestine The insulin has also been reported to increase the cholesterol synthesis The activity of lipoprotein lipase in white adipose is also increased From this point of view, the assessment of various lipid fractions and lipid peroxide in the cases of Diabetes Mellitus may be of some help in the prognosis of patients and in preventing the possibilities of complications or secondary disorders Aim of the study: To study the level of lipid peroxide in IDDM and NIDDM To find out the correlation between Lipid peroxide and Lipid profile in both types of diabetes mellitus Materials and methods: Participants of the study group were selected from the outpatient's population of the Department of Medicine, Government Thiruvarur Medical College, Thiruvarur 100 patients were selected for this study Out of which 50 patients belong to NIDDM and 50 to IDDM group 50 persons served as a healthy control Results: There was a very good positive correlation between MDA and Cholesterol, TGL, LDL, VLDL in both NIDDM and IDDM cases There was a negative correlation between MDA and HDL in NIDDM and IDDM cases Conclusion: In the diabetes mellitus abnormally increased levels of lipid, lipoprotein and lipid peroxides in plasma may be due to the abnormal lipid metabolism The maximum increase in lipid peroxide was found in a group of diabetes mellitus with complication Elevated levels of lipid peroxide in diabetes mellitus may be due to the alteration of function of erythrocytes membrane This inhibits the activity of superoxide dismutase enzyme leading to accumulation of superoxide radicals which cause the maximum lipid peroxidation and tissue damage in diabetes