RESUMEN
Even if life expectancy has increased, sickle cell disease (SCD) still presents difficulties, especially because of the painful episodes that occur frequently and without warning, known as Vaso-occlusive crises (VOCs). These crises are brought on by different cells adhering to one another and obstructing tiny blood veins, which can cause excruciating agony and eventually harm organs and tissues. While the majority of current treatments concentrate on symptom management and pain relief with the use of medications, hydration, and other general approaches, new discoveries about the fundamental mechanisms of VOCs provide intriguing new therapeutic options. With the goal of precisely addressing the pathways causing inflammation and cell adhesion, these cutting-edge treatments may lessen the frequency of VOCs and shield vital organs from harm. Though these treatments provide hope for improved SCD management, careful assessment and analysis of their efficacy and accessibility are necessary to guarantee their general benefit.
RESUMEN
For optimal cervical cancer care pathway, effective communication among colposcopist professionals regarding colposcopic findings, diagnosis, and treatment of intraepithelial lesions is crucial; standardization of the colposcopic report may serve as a beneficial strategy for this purpose. Elaborate and validate the colposcopic report for screening intraepithelial lesions and cervical cancer using a committee of specialists. This validation study used the item-level content validity index (I-CVI) to verify the agreement of judges per item, and the scale-level content validity index (S-CVI) to determine the mean of the proportion of items classified as "no disagreement"; items with an I-CVI?0.80 and S-CVI?0.90 were considered approved. The binomial test was used to select the items that should be revised based on the p value of the proportion (rejecting the H0 if p?0.8); statistical significance was set at p<0.05. Results: Seven judges participated in this study. The 11 items of the Colposcopic Report were validated, but items classified as “disagreement” (1, 2, 5, and 9) or “neither agree nor disagree” (3, 10, and 11) were taken to a consensus meeting. Six of the seven judges of the first stage participated in the consensus meeting. Suggestions for modifying item nine were not accepted, and item 11 underwent a slight modification. The colposcopic report was validated and achieved greater reliability, suggesting its inclusion in the cancer information system.
RESUMEN
Background: Undernutrition is a silent emergency and one of the most common causes of morbidity and mortality among under-5 children throughout the world. A serious public health concern and can have significant effect on child’s overall growth and development. The prevalence of undernutrition is two folds higher among rural area compared with urban area, therefore present study aims to study the prevalence of undernutrition and associated factors among under-5 children living in rural area of Hyderabad. Methods: A community based cross-sectional study was conducted between April 2023 to June 2023 in rural field practice area of a medical college in Hyderabad. A total of 364 under-5 children residing in study area were selected by simple random technique. Data about socio-demographic variables were collected by questionnaire and anthropometrics were measured using standard techniques. Results: In the present study, about 33% of under-5 children are underweight and 35% are stunted. The under-5 children belonged to lower socioeconomic class were significantly more likely to be underweight (40%) and stunted (42%). Family size >6 members were significantly underweight (48%) as well as stunted (47%). Children with low birth weight i.e. <2.5 kg had significantly higher rates of underweight (43%) as well as stunting (45%). Among the children with weaning age less than 6 months, 47% were underweight and 45.6% were stunted. Conclusions: Socio economic status, family size, birth weight, and weaning age are important determinants of undernutrition.
RESUMEN
Meckel's diverticulum is a common anomaly of the gastrointestinal tract, often presenting with various complications. Here, we present a case of a 50-year-old female with a history of hysterectomy and cesarean sections, who presented with symptoms consistent with gallstone ileus. Upon investigation, a Meckel's diverticulum with an associated cholecystoduodenal fistula was identified. Surgical intervention involved resection of the affected intestinal segment and anastomosis, without additional intervention targeting the gallbladder or fistula repair. A systematic review revealed four reported cases of Meckel's diverticulum complicating gallstone ileus in the literature. Our case underscores the importance of considering Meckel's diverticulum in the differential diagnosis of gallstone ileus and highlights the efficacy of a tailored surgical approach.
RESUMEN
Background: Acute coronary syndrome in very young adults (<35 yrs) was considered as an uncommon entity, recently shows rising incidence especially in India. Hence we planned this study with the aim, to investigate the incidence, clinical, angiographic profile and outcome of ACS in this population. Methods: This is a prospective analytical study included patient <35 yrs with ACS admitted to cardiology department in a tertiary hospital of South India. Risk factors, clinical, angiographic profile and follow up data were recorded and analyzed. Results: Among the total 2180 patients with ACS, 5.8% (n=127) were very young adults. Youngest one was 11 yrs old with coronary anomaly. Median age was 30yrs (SD� and only 8.6% (n=10) were obese. Smoking, male sex were the major conventional risk factors followed by low HDL (52%). Family history of premature coronary event seen in 12.9%, hyperhomocysteinemia, elevated LPA and high fibrinogen were observed in 15%, 20% and 3.5% respectively. Anterior wall MI with LAD occlusion was the commonest type (66.3%). Angiographically 31.4% (36/116) had recanalised vessels, coronary anomaly was seen in 3 (2.5%) patients and pure ectasia in 4 (3.4%) patients. Only 2 were undergone primary PCI (1.7%), 61% (n=71) received thrombolytic therapy. Median delay for angiogram was 72 hrs (3 days). In-hospital mortality was 3.4% and 4.5% (n=5) during follow up. Conclusions: The incidence of ACS among very young adults is on the rising trend (5.8%). Obstructive CAD in 56.9% patients implies the rapid progression of atherosclerosis. With little contribution of novel risk markers of atherosclerosis, smoking and dyslipidemia accelerate the process of premature vascular aging in Indian subcontinent.
RESUMEN
Background: A parasitic hydatid disease called liver echinococcosis is brought on by the tapeworm echinococcus and is a reason for concern for global health. In addition to the liver, the lungs can harbor parasites. In the life cycle of parasites, humans occupy a middle position. Depending on the size and intensity of the cyst, the clinical signs can vary and be non-specific. The complications include bleeding, perforation, suppuration, cyst rupture, mechanical jaundice, and portal hypertension. Here is an analysis of own results of surgical treatment of patients with liver echinococcosis in Grodno region, Belarus between June 2012 to October 2022. Methods: The research design was cross-sectional. Diagnostic methods that are instrumental and laboratory-based include a general blood test, a biochemical blood test, an enzyme immunoassay (IFA), abdominal and retroperitoneal MRIs and ultrasounds, abdominal and chest CT scans and brain scans. There were 10 men and 17 women among the 27 patients. The age range of the majority of the patients was 18 to 83. Results: All patients underwent resections, including laparoscopic procedures. One of the patients in our series of cases received a two-stage therapy regimen due to a secondary focus of echinococcosis in the left lung. In our series of cases, no postoperative complications or mortality occurred. Conclusions: Patients with hepatic echinococcosis should be treated at specialized hospitals. Abdominal, chest, and brain CT scans are required in order to search for additional foci. When it comes to treating echinococcosis, minimal invasive surgical procedures should be preferred.
RESUMEN
Background: Poor sleep quality is a global health concern and is fast becoming one of the silent epidemics. Sleep quality among medical students is of particular interest as they are considered high risk groups for developing sleep related issues because of their demanding schedules. This study aims to estimate the magnitude of poor sleep and its correlates among undergraduate medical students of a medical school in Belgaum, India. Methods: An institutional based descriptive cross-sectional study was conducted among 293 undergraduate medical students using a self-administered questionnaire. Sleep quality was assessed using Pittsburgh sleep quality index (PSQI). The potential determinants of quality of sleep were identified using logistic regression. A p<0.05 was considered statistically significant and adjusted odds ratio with 95%CI was used to present the strength of association. Results: The prevalence of poor sleep quality among medical students was 69.3%. Factors like gender, female students (AOR=2.381, 95%CI=1.359-4.172), being overweight or obese (AOR=2.499, 95%CI=1.297-4.817) were associated with poor sleep quality. Students with good sleep hygiene (AOR=0.415, 95%CI=0.231-0.745) and who did not use technology during bedtime (AOR=0.38, 95%CI=0.168-0.878) were less likely of having poor sleep quality at p<0.05. Conclusions: Prevalence of poor sleep quality among substantial proportion of medical students in the current study is alarming. The already existing personal and professional development programme committee can conduct routine screening to assess sleep quality among students and focus on programmes to improve their sleep hygiene.
RESUMEN
The term "gynecomastia" refers to the benign growth of glandular breast tissue in men. In older men, adolescents, and newborns, physiological gynecomastia is common. Although it is self-limited, it can be managed to reduce both physical and emotional discomfort. Chronic conditions (such as cirrhosis, hypogonadism, and renal insufficiency), drug use (including prescription, over-the-counter, and illicit drugs), and tumors are rare causes of nonphysiologic gynecomastia. Exogenous estrogens, antiandrogens, 5-alpha reductase inhibitors, spironolactone, and cimetidine are the active ingredients that are known to cause gynecomastia the most frequently. A patient's medical history is crucial in diagnosing drug-induced gynecomastia. Treating the underlying disease and stopping contributing medications are the cornerstones of treatment. In certain cases, gynecomastia can be treated with surgery and medications such as estrogen receptor modulators. Early intervention and patient-directed care are important aspects of treatment. We describe the pathogenetic mechanism of spironolactone-induced gynecomastia and provide a case report of a 52-year-old male patient.
RESUMEN
Background: The COVID-19, a global pandemic, first identified in the Hubei province (Wuhan), China in December, 2019 is caused by SARS-CoV-2. Attempts of containing it there failed, causing it to spread to other regions of Asia and eventually around the whole world in 2020. To control the risk of transmission, non-pharmaceutical interventions were taken up by the governments all over the world. Subsequently, vaccines were developed which were administered. Vaccine hesitancy has become a significant barrier in various countries due to expeditious pace of vaccine development. Hence, this study was conducted to estimate the COVID-19 vaccination coverage in rural slums of field practice area of a medical college in Hyderabad. Methods: A community based cross sectional study was conducted between January 2023 to March 2023 in field practice area of RHTC of a medical college in Hyderabad. Data was collected from 400 eligible participants, who were selected by simple random sampling, using a predesigned, pretested structured questionnaire. Data was entered in Microsoft Excel and analysed using SPSS Version 20. Chi square test was applied. Results: In the present study, 60% of the study participants had taken COVID vaccine. Vaccination coverage was high i.e., 65.35% among 18-28 years of age group, 82.2% in females, 62.66% in Muslims, 85.71% in graduates, 80.90% in semi-skilled workers and 77.77% in upper middle socioeconomic class. Conclusions: The COVID-19 vaccination coverage was low in rural slums. Age, gender, religion, education, occupation and socioeconomic status are important determinants of COVID-19 vaccination.
RESUMEN
Background: A reduction in turnaround time at any laboratory is critical for early assessment. Our aim of the study was to evaluate the effects of various spin paces and timespans on certain serum electrolyte concentrations, such as sodium (Na+), potassium (K+), and chloride (Cl-). Methods: A cross-sectional, observational study was carried out on 66 apparently healthy volunteers. 10 ml of blood was drawn from each and divided into 4 labelled clot vials (2.5 ml in each vial). Concentrations of serum Na+, K+, and Cl- were assessed in 2 groups (1, 2), each with 33 individuals. Group 1 had varying spin pace parameters (1500 rpm, 2500 rpm, 3500 rpm, and 4500 rpm), and group 2 included various timespans (2 min, 5 min, 10 min, and 15 min). The observations were analyzed using statistical package for the social sciences (SPSS). Analysis of variance (ANOVA) was implied along with a post-hoc Tukey test. A p value of <0.05 was considered statistically significant. Results: Mean concentrations of Na+, K+, and Cl- at different spin paces for a fixed runtime of 2mins had statistically no differences between each other: Na+ (p=0.978), K+ (p 0.999), and Cl- (p=0.997). However, there were statistically significant mean differences at various timespans for Na+ (p<0.001), K+ (p<0.001), and Cl- (p<0.001). Conclusions: Our study concludes that Na+, K+, and Cl- concentrations were not altered at various spin paces. A timespan of 2 mins at 4500 rpm outperformed the benchmarks without affecting the results, signifying that it can be routinely chosen for estimating serum electrolytes such as Na+, K+, and Cl-, effectively lowering turnaround time.
RESUMEN
Prostatic tumours are usually benign. Malignant tumours are usually adenocarcinoma. Rare benign prostate tumours include inflammatory myofibroblastic tumours, which can be found in various body parts and are frequently identified in the lung or abdominal cavity of children and young adults. Inflammatory myofibroblastic tumours of the urinary tract present more often in kidneys. Prostatic inflammatory myofibroblastic tumours are sporadic and rare. Presenting 44 years old male with complaints of gross hematuria for 15 days with recurrent urine retention. Per rectal examination revealed, grade II prostate enlargement was firm in consistency. PSA was mildly raised (4.4 ng/ml). Ultrasound abdomen showed enlarged prostate (volume -40 cc) with irregular margins and heterogeneous echo texture showing increased flow on colour Doppler. Transrectal ultrasound (TRUS) showed a well-defined irregular heterogeneously echoic mass in the transitional zone, but TRUS biopsy showed no malignancy. After TURP, prostate chip examination showed inflammatory myofibroblastic pseudotumour of the prostate. Di?erentiation of inflammatory myofibroblastic prostate tumours from malignant tumours through imaging and laboratory tests is di?cult. A case of prostatic inflammatory myofibroblastic tumour observed after transurethral resection of the prostate to treat prostate hyperplasia in a 44-year-old man is presented in this report.
RESUMEN
The purpose of this study was to quantify the prevalence and co-prevalence of common comorbidities of type 2 diabetes mellitus (T2DM). Literature search was conducted in PubMed for relevant articles published during the period from 2013 to 2023. Studies describing the prevalence rate of T2DM and its associated co-morbidities in INDIA in the past 10 years and the pharmaceutical antidiabetic treatment were identified. Out of 100 articles 10 studies conducted in India fulfilled the inclusion criteria regarding the prevalence rate of T2DM along with its associated co-morbidities. Studies revealed that comorbidity burden tended to increase in older age groups and was higher in men than women. Few studies demonstrated for the combination of hypertension (HTN) and hyperlipidaemia (67.5%), followed by overweight/obesity and HTN (66.0%), overweight/obesity and hyperlipidaemia (62.5%), HTN and chronic kidney disease (CKD) (22.4%), hyperlipidaemia and CKD (21.1%), HTN and cardiovascular disease (CVD) (20.2%), hyperlipidaemia and CVD (20.1%), overweight/obesity and CKD (19.1%) and overweight/obesity and CVD (17.0%). The most common conditions in patients with T2DM included HTN in 82.1%; overweight/obesity in 78.2%; hyperlipidaemia in 77.2%; CKD in 24.1%; and CVD in 21.6%. It was concluded from the study that the vast majority of patients with T2DM have multiple comorbidities. To ensure a comprehensive approach to patient management, the presence of multimorbidity should be considered in the context of clinical decision making.
RESUMEN
Background: Dyslipidemia is a lipoprotein metabolism disorder and a major risk factor for Cardio Vascular Diseases. The National Cholesterol Education Programme (NCEP) guidelines suggest dietary modifications, exercise and weight control as the main foundation of dyslipidemia treatment. Dyslipidemia can be considered as a kapha medoja vikara, managed with correction of agni and kaphamedahara drugs. L?ja (puffed rice) is an aharadravya ideal in this condition because it is having kaphamedahara property. Methods: This study was conducted at Govt. Ayurveda College, Tripunithura as an interventional pre-post study with control group to find out solution for normalizing lipid profile by changing diet without therapeutic medicine. 30 Participants were allotted in each groups by consecutive sampling and advised to follow diet restriction and exercise for both groups. In addition the study group consumed the L?ja peya two times daily before food. Study period was 90 days and assessment taken in 0th, 46th and 91st day. Results: The results showed significant effect on lipid profile in both groups. But in comparison to control group, the study group showed highly significant reduction in Total cholesterol, LDL, VLDL and Triglycerides and not in increasing HDL. Conclusions: L?ja which contains rice bran, low in fat and has Kashaya Madurarasa, lakhu alparooksha guna, agnideepana, kaphachidah and medahara property, that helps to digest the food properly and correct the metabolism. Thus laja peya has a beneficiary role in reducing Total cholesterol, LDL, VLDL and Triglycerides and there is no role in increasing HDL.
RESUMEN
Background: Hepatitis B virus (HBV) infection poses a significant health challenge in Bangladesh, with the hepatitis B core antibody (anti-HBc) being a crucial marker due to its lifelong presence in the bloodstream. This study aimed to evaluate the prevalence of anti-HBc (total) positivity among unvaccinated adults in Northeastern Bangladesh. Methods: This cross-sectional observational study was conducted in the Sobhanighat area of Sylhet, Bangladesh, in collaboration with the department of gastroenterology, Sylhet MAG Osmani Medical College, from November 2022 to August 2023. A total of 216 participants were selected using consecutive sampling. HBsAg, anti-HBs, and anti-HBc (total) were tested for all subjects, and data were collected using a pre-formed questionnaire and analyzed using statistical package for the social sciences (SPSS) version 24. Results: Among the participants, 16 (7.4%) tested positive for anti-HBc (total), while HBsAg was positive in 6 (2.77%) individuals. Anti-HBs was detectable in 23 (10.6%) participants, with 3 (1.38%) showing isolated anti-HBc positivity. Notably, 20% of HBsAg-positive cases exhibited heterotypic anti-HBs. Moreover, 56.25% of respondents with anti-HBc (total) positivity had detectable anti-HBs (p<0.001). Gender did not show significant associations with HBsAg, anti-HBc (total), anti-HBs, or isolated anti-HBc (p>0.05). Conclusions: The study underscores a notable prevalence of anti-HBc (total) positivity among unvaccinated individuals in Bangladesh, indicative of past HBV exposure. It underscores the necessity for enhanced vaccination coverage and robust infection control measures to mitigate HBV transmission in this demographic.
RESUMEN
Onco-fertility, the confluence of cancer and fertility preservation, is vital in modern healthcare. As global cancer survival rates rise, more patients aim to overcome cancer and safeguard their reproductive potential. This review explores onco-fertility in India, emphasizing psychosocial factors. It acknowledges cancer's profound implications on fertility, stressing informed decision-making and comprehensive care for dual challenges. The review explores various preservation options for both genders, highlighting India's evolving landscape. India's onco-fertility landscape, driven by rising cancer diagnoses and disparities, needs tailored services. Understanding psychosocial factors is crucial for addressing emotional distress, cultural contexts, and communication barriers. This review delves into factors influencing decisions and well-being, informing practices to better serve Indian cancer patients. Examining psychological distress and decision-making in balancing treatment and fertility preservation, it explores cultural, religious, and ethical considerations. It underscores the need for comprehensive psychosocial support. Addressing psychosocial factors is vital for enhancing cancer survivors' quality of life. The review emphasizes bridging information gaps, providing emotional support, promoting informed decision-making, and fostering collaboration. It calls for further research and initiatives to advance onco-fertility support, considering India's diverse psychosocial landscape.
RESUMEN
Hypertension is a non-communicable disease in which the pressure of blood pushing against the arterial walls becomes high. In chronic stage it leads to severe systemic diseases, which affects heart, kidney, lung etc. The main causative factors are unhealthy food and lifestyle, stress, smoking, Alcohol, obesity and hereditary. Microalbuminuria in Hypertension is an early sign of kidney damage and is considered as a predictor for the end stage of renal disease and cardiovascular disease. So, it is of great importance to manage microalbuminuria or high urine albumin creatinine ratio and progression of kidney disease in hypertensive patient. In Ayurveda references no proper description of hypertension is available. By viewing the pathogenesis and physiology, it is formed by the involvement of Tridoshas, Srotorodha, and Dhatudushti. The present case is a 60-year male patient was diagnosed uncontrolled hypertension with microalbuminuria, admitted for 1month, presented with complaints such as frothy urine, over tiredness, uncontrolled anger and increased blood pressure during evening time, not controlled by hypertensive modern medicines. His urine albumin-creatinine ratio was 106.98 mg/dl of creatinine, microalbumin in urine 138 mg/dl and uric acid was 11.5 mg/dl. He was advised the internal Ayurveda medicines, diet restriction and yogic breathing exercise. Within one month of treatment the urine albumin creatinine ratio and uric acid was reduced and became normal. His blood pressure also became controlled and recovered all symptoms. Ayurvedic treatment module appears to be safe and efficacious with early recovery and better outcomes in this case.
RESUMEN
Background: Globally an estimated two to three million deaths occur every year in all age groups, from six major vaccine-preventable diseases and accounts for almost a quarter of all deaths in children under the age of five years. As Immunization is one of the most successful and cost-effective methods for preventing infectious diseases, the Indian government initiated a vaccination programme to reduce infant mortality and morbidity owing to vaccine-preventable diseases, and achieve vaccine self-sufficiency. In Kerala, about 1.5% of the total population makes up Scheduled Tribes, a socioeconomic group with continuously poor health indicators. Methods: Through a community-based cross-sectional study using cluster sampling technique, this study intends to determine the coverage of the universal immunization programme among tribal children (0-59 months), the factors affecting vaccination coverage as well as the reasons for partial immunization in Noolpuzha Panchayat, Wayanad. A semi-structured questionnaire was used to collect information from caregivers/mothers. Results: Out of 289 study population, 64.4% were fully immunized and 35.6% were partially immunized. Children's age and the father's education were found to affect immunization. Conclusions: As a lack of knowledge about immunizations and subsequent doses was the primary reason for partial immunization. There is a need to create awareness about the importance of vaccination and the subsequent doses among the tribal people of Wayanad.
RESUMEN
Background: Genital pruritus is a common complaint among women, the cause of which could be multitude. Identification of these causes can lead to prompt resolution of pruritus with appropriate therapies. The objective of our study was to determine the clinical profile of genital pruritus and its impact on quality of life amongst all female patients attending Dermatology OPD at our tertiary care centre. Methods: An observational, descriptive, cross-sectional study conducted from June 2020-May 2021on 196 female patients attending the dermatology OPD with primary complaints of genital pruritus. Diagnosis was established by history and clinical examination and confirmed by bed side tests and laboratory investigations as and when required. Results: The mean age of the patients was 36.87�.24 years with 41.8% in the age group of 18-35 years. In majority (47.4%) of patients, itch was of moderate severity according to the Numerical rating scale. Infectious diseases (45.9%) were the most common cause followed by inflammatory (33.2%), idiopathic (19.4%) and hormonal (1.5%). Vulvovaginal candidiasis was by far the commonest (36.2%). The most common inflammatory dermatoses were lichen simplex chronicus (12.2%) followed by lichen sclerosus atrophicus (10.2%) and contact dermatitis (6.1%). 7 patients with idiopathic itch were diagnosed to have an underlying psychiatric illness. Conclusions: As genital pruritus has multiple causes, proper categorization and diagnostic evaluation would be appropriate to achieve optimal treatment to meet the diverse needs of women who suffer from it.
RESUMEN
Epididymo-orchitis is an inflammatory lesion of the testis and epididymis with a lymphocytic exudate. Patients with acute epididymo-orchitis typically present with scrotal pain, swelling, tenderness and fever. Here, we present a patient with scrotal pain and hemiscrotal swelling as the main complaints; however further investigations revealed a completely different and rare diagnosis. Zinner抯 syndrome is a very rare developmental anomaly of the Wolffian duct. To date, only about 200 cases have been diagnosed. It is a triad of unilateral renal agenesis, ipsilateral seminal vesicle cyst and ejaculatory duct obstruction. Some patients remain asymptomatic and discovered incidentally, while others present with symptoms related to seminal vesicle cysts or ejaculatory duct obstruction: voiding or ejaculatory difficulty or pain. Treatment options include transurethral or transrectal aspiration and percutaneous drainage, however both are linked to an increased risk of recurrence. Symptomatic, complicated and recurrent cyst will require excision of the cyst, either laparoscopically or robotically.
RESUMEN
Tyrosinase is an important copper-based enzyme mainly involved in skin pigmentation. The inhibition of the tyrosinase enzyme attracts importance in cosmetic and medicinal chemistry industry for its applications in skin whitening and anti-browning agents for humans as well as in food, agriculture industries. Imidazole based Metronidazole and its derivatives are widely accepted drug for wide range of diseases. Therefore, the present report involves the synthesis of heterocyclic derivatives of metronidazole and investigation of its efficacy towards the tyrosinase inhibitory activity. A series of metronidazole esters were synthesized and their chemical structures were confirmed using spectral techniques like, infrared spectroscopy (IR), proton nuclear magnetic resonance (1H-NMR), and liquid chromatography-mass spectrometry (LC-MS). All the compounds were evaluated for its tyrosinase inhibitory activity by oxidation of 3,4-dihydroxyphenylalanine in the presence of the synthesized esters(I-VIII) with kojic acid as standard. Among the synthesized compounds, VII (isonicotinic ester) and VIII (quinoline ester) demonstrated significant activity IC50 values 92.5 and 91.8µM respectively. Further molecular docking experiments were carried out for the synthesized compounds with 2y9w protein exhibited greater number of physical interactions for compounds VII and VIII than the other compounds in the series confirming the mushroom tyrosinase activity.