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Background: Magnetic Resonance imaging (MRI) is essential for assessing intracranial malignancies, but conventional MRI has limitations in tumour grading and infiltration information. Advanced Magnetic Resonance (MR) sequences, such as diffusion-weighted (DW) and Magnetic Resonance spectroscopy (MRS), can differentiate between low-grade and high-grade tumours, aiding treatment decisions. This study aims to evaluate the efficacy of diffusion-weighted imaging and magnetic resonance spectroscopy in grading intra-axial brain tumours and correlating the results with histopathology. Methods: This retrospective study involved 45 patients over one year at Apollo Hospital. MR imaging included conventional sequences, DW, and MRS with localizers in all three planes. DWI and ADC maps were obtained using specific b-values. Standard mean Apparent Diffusion Coefficient (ADC) values were automatically calculated for intra-lesional and peri-lesional regions. Results: Intralesional ADC values did not significantly differ between high-grade primary tumours (0.4-1 x 10-3 mm2/s, mean 0.7) and metastases (0.4-0.8 x 10-3 mm2/s, mean 0.7). However, peri-lesional ADC values were lower in primary tumours (0.3-1.3 x 10-3 mm2/s, mean 0.8), indicating peri-lesional infiltration, while higher in metastases (1.2-1.6 x 10-3 mm2/s, mean 1.4) due to the absence of peri-lesional infiltration. Additionally, intralesional ADC values showed a significant difference between low-grade tumours (1-2 x 10-3 mm2/s) and high-grade tumours (0.4-1 x 10-3 mm2/s), allowing for their distinction. There were significantly increased Cho/NAA and Cho/Cr ratios in high-grade tumours compared to low-grade tumours. Conclusions: MR spectroscopy and DWI with computation of ADC values can enhance the diagnostic effectiveness of MR imaging in detecting and grading malignant brain tumours.
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Rhabdomyosarcoma (RMS) is a rare and in adult accounts for only 1-3% of all malignant soft tissue tumors. The most frequent sites of origin is within head and neck area. One of the least common sites is the retrorectal-presacral space. This case of 61 years old female is probably the fifth well-documented case of primary abdominopelvic RMS. She presented with abdominal distensions, obstipation, vomiting for 5 days. Excision of the gut wall along with soft tissue mass was done and sent to our department for histopathological examination. On microscopic examination, a diagnosis of malignant mesenchymal tumor with closest resemblance to RMS was made. It is a rare case and needs to bring in notice as there is very few information regarding intraabdominal RMS. This case initially thought to be metastasis from gynecologic malignancy. It is important for pathologists, gynecologists and radiologists to recognize RMS as differential diagnosis of masses arising in abdomen and pelvis.
RESUMEN
Rhabdomyosarcoma (RMS) is a rare and in adult accounts for only 1-3% of all malignant soft tissue tumors. The most frequent sites of origin is within head and neck area. One of the least common sites is the retrorectal-presacral space. This case of 61 years old female is probably the fifth well-documented case of primary abdominopelvic RMS. She presented with abdominal distensions, obstipation, vomiting for 5 days. Excision of the gut wall along with soft tissue mass was done and sent to our department for histopathological examination. On microscopic examination, a diagnosis of malignant mesenchymal tumor with closest resemblance to RMS was made. It is a rare case and needs to bring in notice as there is very few information regarding intraabdominal RMS. This case initially thought to be metastasis from gynecologic malignancy. It is important for pathologists, gynecologists and radiologists to recognize RMS as differential diagnosis of masses arising in abdomen and pelvis.
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A sulfated polysaccharide (SPSG) was successfully isolated from seagrass Halodule wrightii Asch., Cymodoceaceae, and its antioxidant and anticoagulant activities were investigated. The data presented here showed that the SPSG is a 11 kDa sulfated heterogalactan with a sulfatation degree of 20.63 percent and it also contains glucose and xylose. SPSG antioxidant activities were evaluated using several in vitro assays and the anticoagulant activity was evaluated by aPTT and PT tests. These assays suggested that the SPSG possessed remarkable antioxidant properties in different in vitro assays and an outstanding anticoagulant activity 2.5-fold higher than that of heparin Clexane® in the aPTT test. This data represents the first reported on the sulfated polysaccharide biological activities from seagrass. These results indicate that SPSG can be considered in the future as a drug utilized in treating diseases from these systems.
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Resumo: O presente artigo refala uma nova experiência de metodologia de ensino -aprendizagem descritas pelos próprios monitores, desenvolvida no curso de Medicina da Universidade Estadual de Londrina, junto à disciplina de Semiologia. Esta monitoria acadêmica caracterizou-se pelas seguintes inovações: 1) Autonomia do monitor na elaboração do programa de atividades e, 2) Avaliação concomitante do método, através de questionários elaborados pelos monitores, aplicados periodicamente com o objetivo de identificar e caracterizar os principais fatores, prejudiciais e/ou benéficos, a fim de otimizar tal atividade acadêmica. Os autores descrevem o processo de seleção dos monitores, atividades desenvolvidas, dificuldades encontradas, resultados obtidos, e concluem que a modalidade de ensino com a utilização de monitores, mostra-se de extrema utilidade e importância no processo de formação médica, propiciando a transmissão de conhecimentos, aquisição de raciocínio crítico e estímulo à futura carreira universitária.
Summary: This article describes a new experiences of teaching methodology developed by the Medical Anamnesis and Physical Diagnosis at the School of Medicine of Universidade Estadual de Londrina. This academic teaching methodology was caracterized by: 1) The independence of the monitors to determinate the schedule of the activities and, 2) Continuous evaluation of the method, applied periodically to identify the major problems in order to improve the teaching method. The authors describe the selecting process of the monitors, activities carried out, unexpected difficulties, results anel conclude that· the proposed methodology is extremely useful in Medical Education and play an important role in improving knowledge, reasoning and stimulating a future University carrier.