Comparison of pharmacokinetics of two preparations of cyclosporine in end stage renal disease patients on maintenance haemodialysis

To compare the pharmacokinetics and tolerability of two preparations of cyclosporine. The bioavailability of two preparations of cyclosporine [Panimun Bioral, Panacea Biotec India and Sandimmun Neoral, Novartis Switzerland] was compared in 10 adult patients of ESRD on maintainence haemodialysis by enzyme multiplied immunoassay technique [EMIT] after 6.5 days of cyclosporine [5 mg/kg body weight/day in two divided doses] of either brand, with a clearance period of one week in between the two. Area under the curve [AUC], maximum whole blood concentration [Cmax], time to achieve Cmax [Tmax], half life [T1/2], constant of elimination [Kel] was calculated by computer software programme [PK Solutions]. The relative bioavialability of Panimun Bioral was 93%. The AUC [0-12] hours. Cmax Tmax, T1/2 and Kel was not statistically significantly different and side effects with both were minimal. The two preparation were bioequivalent

Re-evaluation of uterine packing for postpartum haemorrhage

A retrospective study was conducted at the Department of Obstetrics and Gynaecology [Unit II], Liaquat Medical College Hospital, Jamshoro, Hyderabad, with the objective of determining the use of uterine packing for control of postpartum haemorrhage [PPH] and to evaluate the efficacy and complications of the procedure. Data was collected from the obstetric records of all the deliveries over a period of five years, from January 1992 to December 1996. All women who had undergone uterine packing for control of postpartum haemorrhage were identified and indications and postoperative complications analysed

analysis of maternal deaths in hospital in Hyderabad

During the 6-year period from 1990 to 1995 maternal deaths which occurred in Unit I and Unit II of the Department of Obstetric and Gynaecology, Liaquat Medical College and Hospital, Hyderabad were analysed in depth. During the period of study were 268 maternal deaths, 12.940 deliveries and 11.542 live births. Thus, the maternal mortality ratio was 23.12/1000 live births [20.71/1000 total births]. The main cause of maternal deaths was sepsis followed by eclampsia. When compared to the study carried out during 1986-1990 in the same institution there appears to be no significant change in the trend of maternal mortality. This reflects that the socio-economic and health care services are still grossly inadequate in quality and quantity

Obstetric hysterectomy

A review of 83 cases of obstetric hysterectomy performed at Liaquat Medical College Hospital over a period of 30 months from January 1992 to June 1994. During same period 9685 deliveries were conducted, giving an incidence of 1 obstetric hysterectomy per 116 deliveries. The most common indication for obstetric hysterectomy was uterine rupture 42[17%], leiomyoma 2[2.4%] and established uterine infection 6[7.2%]. In 62% of hysterectomies performed for uterine rupture, the etiological factors appeared to be obstructed labour or oxytocin augmentation. In 48% of hysterectomies performed for placenta accrela there were one or more previous Caesarean sections

Advanced germ cell tumour of ovary in pregnancy

A case of advanced germ cell tumour of ovary [dysgerminoma] in pregnancy is being described. The entity is usually difficult to diagnose. Utilizing conservative surgical procedures in young females in the early stages of the disease, fertility can be conserved