direct, rapid and sensitive high - performance liquid chromatographic method for the determination of diclofenac sodium and its application in bioailability studies

A simple [extraction less], rapid and sensitive reversed phase high-performance liquid chromatographic method, with ultraviolet detection at 280 nm, was developed to measure diclofenac sodium in plasma at concentrations suitable for bioavailability studies. Flufenamic acid was used as internal standard and the separation was performed at ambient temperature on a mg-Bondapak C18 column. The mobile phase consisted of a mixture of acetonitrile and 0.05 M phosphate buffer [1:1 v/v]. The pH of the mixture was adjusted to 3.5 using phosphoric acid. The limit of quantitation of diclofenac sodium was 0.05 mug/ml and the time for separation of each sample was no longer than 6.5 minutes at a flow rate of 2 ml/minute. The study of the inter- and intra-day precision and relative recovery study proved that the suggested method is accurate, sensitive and reproducible. The method was applied to test the bioavailability of the enteric coated diclofenac sodium tablets [Voltaren] in Beagle dogs

Formulation and physicochemical evaluation of diclofenac sodium chewable tablets

Taste masked diclofenac sodium, by three techniques, namely microencapsulation with ethylcellulose, ethylcellulose pan coating and 'inclusion complexation with beta-cyclodextrin followed by coating with an aqueous dispersion of ethylcellulose [Aquacoat], was formulated into chewable tablets. After several trials, three formulae, one for each type of the treated diclofenac sodium, were selected. The chosen three formulae were directly compressed into 10 mm diameter flat tablets containing 25 mg of diclofenac sodium and weighing about 600 mg. The produced tablets were evaluated with regard to their taste profile in addition to uniformity of dosage, friability, hardness and dissolution. The obtained results indicated that the three different batches of diclofenac sodium chewable tablets had good to excellent taste except for that based on diclofenac sodium-beta-cyclodextrin inclusion complex. The three batches complied with the pharmacopoeal [USP XXIV] requirements with regard to uniformity of dosage and friability and they showed reasonable hardness values. With regard to the in vitro release profile [in phosphate I buffer pH 7.4], two of the three chewable tablet batches showed fast release profiles, whereas the batch based on diclofenac sodium microcapsulcs showed a relatively slow release pattern

Role of computed tomography in gastric neoplasms

Gastric neoplasms often form a diagnostic problem to the examining clinician.Fourty nine patients with gastric neoplasms represent the material for this study, 19 were males and 30 were females; their ages ranging between 29-66 years. CT scans and barium studies were done for all af them. Endoscopic examination was carried for 38 and surgical interferance was done for 27. CT studies have proved, from our work, to be very useful in detection and evaluation of gastric neoplasms

Role of computed tomography in ovarian cystadenoma

Ovarian cystadenomas are common ovarian neoplasms. The relatively infrequent use of computed tomography [CT] compared to ultrasound [US] in evaluating the adnexae has resulted in a paucity of information in the literature regarding the CT features of ovarian masses. This study comprised 26 female patients with ovarian cystadenomas, their ages ranging between 21 -.67 years. Pelvic CT and pelvic sonography were carried, for all of them and 19 were operated upon.The CT features we have encoutered are throughly described and so is the possible differential diagnosis. Accordingly, we state our own opinion to where CT scanning of the pelvis stands as a diagnostic tool for such lesions

Significance of computerized tomographic examination in cases of mediastinal goiter

Mediastinal thyroid is one of the most common causes of mediastinal masses. Thoracic Computerized Tomographic scans [TCTS] were performed for 17 patients with mediastinal thyroids, 11 were males and 6 were females; their ages ranging between 41 - 80 years. Radionucleide [131] I study was carried for 15 patients and thoracotomy was done for 6. We have found that CT scanning in most instances is capable of specifically identifying mediastinal goiters. This identification should eliminate diagnostic thoracotomy in these patients and minimize the neccessity for [131] I scans in patients with mediastinal masses noted on chest radiograms. CT is also capable of providing useful anatomic and physiologic information as being an accurate mean for follow up