Condensed thieno [2,3-d] pyrimidines: synthesis and biological activity

The synthesis of several new [1] benzothieno [3, 2-e] [1, 2, 4] triazolo [4, 3-a] pyrimidines and [1] benzothieno [3, 26 5, 6,] pyrimido [2, 1-c] [1, 2, 4] triazines is described. Evaluation of some of the new compounds as anti-beta-lactamase, analgesic and anti inflammatory shows promising results

New 4-quinazolinones as antibacterial agents

The synthesis of several new 3-[4-[arylidenehydrazino- carbonylmethyloxy] phenyl]-2-methyl-7-nitro-4 [4 93H0-quinazolinones is described. Cyclization of these hydrazones under different reaction conditions afforded the expected 5-substituted thio-oxadiazole as well as 4-acetyl-5-substituted oxadiazoline derivatives. The antibacterial activity of some of the obtained compounds is evaluated. The constitution of the new products is proved in the light of their microanalyses and nmr spectral data