RESUMEN
Human peripheral blood lymphocytes from 10 patients with familial adenomatous polyposis (FAP) showed a significantly higher incidence of chromatid breaks when compared to cells from 10 normal individuals, after exposure to bleomycin (BLM) during the G2 phase. However, no significant increase in bleomycin sensitivity was observed in lymphocytes from 10 patients with sporadic adenomatous polyps (AP) vs. 10 normal individuals (P = 0.67). Individuals that exhibited an average number of chromatid breaks per cell higher than 0.80 were considered sensitive to the drug. No control showed susceptibility to BLM, as compared to 3 out of 20 patients.
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Persona de Mediana Edad , Antibióticos Antineoplásicos/farmacología , Bleomicina/farmacología , Cromátides , Poliposis Adenomatosa del Colon/tratamiento farmacológico , Anciano de 80 o más Años , Rotura Cromosómica , Linfocitos/efectos de los fármacos , Síndrome de Gardner/tratamiento farmacológico , Intercambio de Cromátides HermanasRESUMEN
Relato do caso de um paciente com queixa de disfagia rapidamente progressiva, cujos exames radiológico e endoscópico demostraram a presença de lesao estenosante do terço distal do esôfago. A biopsia da mesma revelou a presença de fungos, cuja cultura mostrou tratar-se de Histoplasma capsulatum. A dilataçao endoscópica da lesao, indicada por falha do tratamento clínico específico, provocou ruptura esofágica. Foi realizada esofagectomia subtotal com remissao dos sintomas.