Quality control and drug-drug interactions between commercially available Metoprolol and Glimepiride tablets

Abstract Quality is paramount and needs to be maintained throughout the shelf life of pharmaceuticals. The current study aimed to evaluate the quality, potency, and drug-drug interaction in an in vivo animal model by using two drugs, namely, metoprolol and glimepiride. Tablets were selected for their physical characteristics, such as shape, size, and color. Quality control tests, such as weight variation, hardness, friability, and disintegration tests, and invitro drug release studies were performed as per USP. Drug-drug interaction and in vivo studies were carried out according to the standard protocol of the animal ethics committee. Quality control tests of both the tablets were within the specified range. The cumulative release percentages of the drugs were 81.12% and 85.36% for Metoprolol Tartrate and Glimepiride, respectively, in a physiological buffer solution within 1 h. The combination of metoprolol and Glimepiride also significantly decreased the blood glucose level in diabetic animals. However, the blood glucose level increased in the group receiving metoprolol only, but the difference was not significant. The result suggested that the formulations are safe. However, the chronic use of this combination requires frequent monitoring of blood glucose level to improve its efficacy and for the patient's safety.

Relationship between the family environment and childhood obesity

Objective: To determine the association of family environment with childhood obesity

Methodology: This case control study was conducted in Public and Private schools of Lahore city and was analyzed in Department of Community Medicine, Allama Iqbal Medical College Lahore from November 2015 to May 2016.Students having age 8 to 10 years studying in grade 4 and 5 were selected for this study

Results: After compiling the results, it was noted that childhood obesity was associated with parental BMI, eating between regular meals, TV viewing >4hours/day and physical activity <20min/day

Conclusion: Results of this study revealed that childhood obesity is associated with risk factors of family environment [parental BMI, eating between regular meals, TV viewing >4hours/day and physical activity <20min/day]

Euphorbia dracunculoides lam. [Euphorbiaceae]: a new record to the flora of Yemen

Euphorbia dracunculoides Lam. [Euphorbiaceae] is reported as a new record for the flora of Yemen. The specimen was collected from Al-Kaud village, Abyan governorate. This new record was compared with similar species in Yemen. Description, distribution, and figures of this new record are given