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1.
Medical Journal of Cairo University [The]. 2006; 74 (Supp. 1): 109-112
en Inglés | IMEMR | ID: emr-79423

RESUMEN

To examine the possible participation of the Fas/Fas ligand [Fas-L] system and tumor necrosis factor-alpha [TNF-alpha] in the pathogenesis of acute and old myocardial infarction [AMI and OMI] in a trial to explore the role of immune mechanisms in the pathogenesis of these conditions. Serum levels of sFas, sFasL and TNF-alpha were measured in 10 patients with AMI, 12 patients with OMI and 15 normal subjects as control group. We excluded AMI patients with congestive heart failure, concomitant inflammatory disease, cancer or other significant heart diseases. Serum levels of sFas, sFas ligand and TNF-a were determined by ELISA. Serum levels of sFas and TNF-alpha were greater than normal only in patients with AMI compared to normal subjects, however, there was no difference among serum levels of sFasL for all groups. We found that circulating levels of sFas and TNF-alpha in patients with AMI increase during the early phase of disease whereas levels of sFas ligand remained unchanged. Therefore circulating sFas and TNF-a could play an important role as marker of pathophysiologic conditions associated with cardiomyocyte apoptosis in AMI


Asunto(s)
Humanos , Masculino , Femenino , Apoptosis , Factor de Necrosis Tumoral alfa , Receptor fas , Ensayo de Inmunoadsorción Enzimática
2.
Medical Journal of Cairo University [The]. 2005; 73 (3): 597-601
en Inglés | IMEMR | ID: emr-73377

RESUMEN

To investigate whether Angiotensin II [AII] plays a role in the development of proliferative diabetic retinopathy [PDR] and diabetic macular edema [DME] in combination with vascular endothelial growth factor [VEGF], which is considered to be the most potent factor in promoting angiogenesis. Therefore, we investigated the relation between the plasma and vitreal levels of AII and VEOF in patients with DME and PDR. Plasma and vitreous samples were obtained simultaneously from 6 subjects with DME and 14 subjects with PDR compared to 8 subjects with macular hole as controls. The VEGF levels in vitreous fluid and plasma were determined by a competitive enzyme immunoassay [EIA], while AII levels were measured by a competitive RIA. The vitreous fluid levels of VEGF and All were significantly higher in DME and PDR than in macular hole group [p < 0.05], [p < 0.01], [p < 0.001], [p < 0.001] respectively. VEGF and AII in vitreous of subjects with DME and PDR were also significantly higher than plasma levels p < 0.001]. The vitreous level of AII was significantly positively correlated with that of VEGF in the PDR and DME groups. We found that the levels of AII and VEGF were significantly elevated in vitreous of patients with DME and PDR. Our results suggest that there is a significant relation between VEGF and All, and they are related to increase vascular permeability in DME and PDR


Asunto(s)
Humanos , Masculino , Femenino , Endotelio Vascular , Factores de Crecimiento Endotelial , Angiotensina II , Edema Macular , Cuerpo Vítreo , Enfermedades de la Retina/etiología
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