A study to assess effectiveness of video assisted teaching programme on gastro intestinal tract assessment among student nurses of tertiary care hospital: a statistical approach

Background: The gastro intestinal is important system in the human body. Many times it is found that its uneasy for student nurses to check the patient. So, there is need to improve the available learning programmes regarding gastro intestinal tract assessment.So, it was necessary to conduct this study for educating student nurses regarding the gastro intestinal tract assessment to improve their knowledge. The objectives of this study were to assess the knowledge of student nurses regarding gastro-intestinal tract assessment and to evaluate the effectiveness of video assisted teaching programme on knowledge regarding gastro intestinal tract assessment.Methods: Material and methods used for the study is the evaluative approach; one group pre test, post test design was used. Study was conducted on sample of 70 student nurses by using convenient sampling technique. The data were collected by structured questionnaire. The data were analyzed using descriptive and inferential statistics.Results: The mean knowledge score of student nurses during the pre-test was 39.89% where as it had raised up to 72% during the post-test regarding gastro intestinal tract assessment as effectiveness of video assisted teaching programme. Therefore, the difference assessed was 32.11% between pre-test and post-test.Conclusions: There was significant difference between the pre-test knowledge level and post-test knowledge level of student nurses on gastro intestinal tract assessment. Hence health education programs and on-going teaching both can further improve the knowledge of student nurses.

Knowledge, Attitude, Practices Of Disulfiram Amongst Relatives Of Patient With Alcohol Use Disorder

KAP (Knowledge, Attitude and Practice) studies are highly focused evaluations to measure changes in response to a specific intervention, usually outreach, demonstration or education. This study was conducted to assess KAP of Disulfiram amongst relatives of patients suffering from alcohol use disorder. Relatives of 100 patients diagnosed as alcohol use disorder were interviewed using a self–designed semi structured proforma. Alcohol use was documented to ascertain the pattern and dependence. On asking if “Heard about disulfiram” 38 respondents stated yes whereas 62 said no.36% said that they have used disulfiram.32% reported good experience.35% showed improved quality of life and achieved abstinence from alcohol.The present study demonstrated poor knowledge among relatives, but good attitudes toward use of disulfiram. The results suggest the need to implement an intervention strategy that reflects specific local circumstances and plan activities that are suited to the population involved.

study to evaluate prescribing pattern of antibiotics among patients of urinary tract infection with preexisting renal disorders in a tertiary care hospital.

Background: Urinary tract infection (UTI) is one of the most common bacterial infections encountered and treated worldwide. The objective was to determine the incidence, culture-sensitivity status, prescription pattern of antibiotics and response to various antibiotics and other therapeutic considerations in patients of complicated UTI (cUTI). Methods: The observational prospective analytical study conducted in Department of Nephrology, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai. Results: A total percentage of patients having UTI was 13.08%. Of these 200 patients, 119 patients were female (60%) and 81 patients were male (41 %). Among male, the prevalence was seen more in geriatric age group and among female in adult group. Symptomatologically, fever was the most common symptom. Among male, diabetes mellitus was most commonly associated with cUTI whereas recurrent UTI were more common among female. Of the 200 patients, culture sensitivity was done in 133 patients. Escherichia coli was found to be the most common organism. Quinolones were the most commonly prescribed first line drug followed by beta-lactamase inhibitors. Combinations such as cefoperazone + linezolid were the most commonly prescribed second-line drug, followed by combination of ceftriaxone or cefoperazone with metronidazole. Paracetamol was the most common non antibiotic support given. Conclusions: The results of this study may not be representative of the general population; but UTIs are often treated empirically, and susceptibility tests are often carried out only when the patient has failed one or more courses of antibiotics.

Drug-induced nephrotoxicity.

Drug-induced nephrotoxicity is an extremely common condition and is responsible for a variety of pathological effects on the kidneys. Drug-induced acute renal failure (ARF) accounted for 20% of all ARF cases. Drugs showed to cause nephrotoxicity exert their toxic effects by one or more common pathogenic mechanisms. Although it is impossible to present all the drugs causing the nephrotoxicity, this article will summarize the mechanism of injury associated with particular common medications, discuss clinical presentations, renal markers, and evaluate strategies that prevent or minimize renal injury. Drug-induced nephrotoxicity tends to be more common among certain patients and in specific clinical situations. Therefore, successful prevention requires knowledge of pathogenic mechanisms of renal injury, patient-related risk factors, drug-related risk factors, and preemptive measures, coupled with vigilance and early intervention. General preventive measures include using alternative nonnephrotoxic drugs whenever possible; correcting risk factors, if possible; assessing baseline renal function before initiation of therapy, followed by adjusting the dosage; monitoring renal function and vital signs during therapy, and avoiding nephrotoxic drug combinations. Surprisingly, little information is available to guide us with respect to avoiding complications in critical illness; therefore, it is necessary to follow the guidelines.

Detoxification of Abrus precatorius L seeds by Ayurvedic Shodhana process and anti‑inflammatory potential of the detoxified extract.

Background: Abrus precatorius seeds traditionally used for the treatment of sciatica and alopecia contains the toxic protein, abrin, a Type II Ribosome Inactivating Protein. Ayurveda recommends the use of Abrus seeds after the Shodhana process (detoxification). Objective: The current study was aimed at performing the Shodhana process, swedana (boiling) of Abrus precatorius seeds using water as a medium and to evaluate the anti‑inflammatory potential of seed extract post detoxification. Materials and Methods: Non‑detoxified and detoxified extracts were prepared and subsequently subjected to various in vitro and in vivo assays. In hemagglutination assay, the non‑detoxified extract shows higher agglutination of RBCs than detoxified extract indicating riddance of toxic hemagglutinating proteins by Shodhana. This was confirmed by the SDSPAGE analysis of detoxified extract revealing the absence of abrin band in detoxified extract when compared to non‑detoxified extract. Results: The cytotoxicity assay in HeLa cell line expresses a higher reduction in growth percentage of the cells with non‑detoxified extract as compared to detoxified extract indicating successful detoxification. Brine shrimp lethality test indicated the reduction in toxicity index of detoxified extract as compared to non‑detoxified extract. Further, the whole body apoptosis assay in zebrafish revealed that percentage of viable cells were greater for detoxified extract than non‑detoxified extract. The anti‑inflammatory studies using carrageenan induced paw edema model in rats was carried out on the extracts with doses of 100 mg/kg and 200 mg/kg, per oral, where the detoxified extract exhibited significant inhibition of rat paw edema at both the doses comparable to that of Diclofenac sodium. Conclusion: Absence of toxicity and the retention of the anti‑inflammatory activity of detoxified Abrus seed extract confirmed that the Swedana process is effective in carrying out the detoxification without affecting its therapeutic potential.

Cytokine expression pattern in milk somatic cells of subclinical mastitis-affected cattle analyzed by real time PCR / 대한수의학회지

The expression profiles of inflammatory cytokines viz. interleukins (IL)-6, IL-8, IL-12, granulocyte macrophage-colony stimulating factor, interferon-gamma and tumor necrosis factor-alpha in response to subclinical mastitis in indigenous cattle breed Kankrej (n = 6), Gir (Bos indicus) (n = 12) and crossbred (Bos taurus x Bos indicus) (n = 7) were investigated using quantitative real time PCR. Significant correlation (p < 0.05) was observed between total bacterial load and somatic cell count (SCC) in all three breeds of cattle. All the cytokines were observed to be up-regulated compared to cows with healthy quarters, however, level of their expression varied among three breeds of cattle. In Kankrej most cytokines were found to be transcribed to higher levels than in other two breeds; the milk had higher load of bacteria but not so high SCC, implying that Kankrej has a higher inherent resistance against mastitis. The results of present study indicated that mammary glands of crossbred cattle are more sensitive to bacterial infection than indigenous breed of cattle as they elicit immune response at lower bacterial load and result into higher SCC. Research on identification of factors responsible for differentially expressed cytokines profiles and use of cytokines as immunomodulatory tools can pave way for formulating control strategies against bovine mastitis.

Awareness about biomedical waste management and infection control among dentists of a teaching hospital in New Delhi, India.

All 64 dentists working in a teaching hospital of New Delhi participated in a survey. A pre-tested self-administered questionnaire was used to assess knowledge and practices of biomedical waste management and infection control among these dentists. The results show that not all dentists were aware of the risks they were exposed to and only half of them observed infection control practices. In addition to this, majority of them were not aware of proper hospital waste management. The dentists need to be educated on Biomedical Waste (Management & Handling) Rules, 1998 through extensive training programme.