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Indian Heart J ; 1997 Jul-Aug; 49(4): 383-6
Artículo en Inglés | IMSEAR | ID: sea-4113

RESUMEN

In order to clarify the role of thrombolytic therapy for treatment of prosthetic valve thrombosis, all cases admitted in the intensive care unit (ICU), between March 1987 and March 1997 with the diagnosis of prosthetic valve thrombosis and treated with streptokinase, were analysed. In total, 42 patients with clinical and echocardiographic evidence of left side tilting disc prosthetic valve thrombosis were treated. All the patients had only mitral valve prosthesis involvement. Streptokinase was administered as a bolus of 2.5 lac units over 30 minutes followed by 1 lac units/hour for 48-72 hours. Thirty-seven (88%) patients had successful thrombolysis. Overall mortality occurred in 9.5 percent patients due to systemic embolism and bleeding complications. Serial clinical, radiological and echocardiographic studies showed successful thrombolysis in 88 percent patients. This study demonstrates that streptokinase therapy is safe and effective first line treatment for left-sided prosthetic valve thrombosis and surgery should be reserved for those patients who fail to respond to thrombolytic therapy.


Asunto(s)
Adolescente , Adulto , Distribución por Edad , Países en Desarrollo , Femenino , Fibrinolíticos/uso terapéutico , Implantación de Prótesis de Válvulas Cardíacas/efectos adversos , Humanos , Incidencia , India/epidemiología , Masculino , Persona de Mediana Edad , Distribución por Sexo , Estreptoquinasa/uso terapéutico , Tasa de Supervivencia , Terapia Trombolítica/métodos , Trombosis/tratamiento farmacológico
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