RESUMEN
Many associations have been found between specific HL.4 antigens and increased susceptibility to various diseases. So we tried to associate class I and class II antigens with acute lymphoblastic leukemia. We also demonstrate the presence of antibodies in serum of acute lymphoblastic leukemia patients against HLA class I. Prospective study. Tissue typing and histocompatibility center at .Al-Karamah Teaching Hospital. 70 acute Lymphoblastic leukemia patients from pediatric hospitals. HLA [human leukocyte antigens [typing done for them by serological method and cross matching and blood grouping were also done for them. there was significant difference between patients and control groups regarding HLA -C6, D R1, DR4, DR7, DQI, DQ2, DQ3, DQ4. There was14.2% [1 0/70] of patients had antibodies against HLA class I. There were two significant associations between blood group and acute lymphoblastic leukemia. Genetic factor increased susceptibility with acute lymphoblastic leukemia HLA- DRI DQI, HLA - DR4 DQ4, HLA- DR4 DQ3, and HLA- DR7 DQ2. This HLA typing increased susceptibility to be affected with leukemia after infection. HLA typing was done to acute lymphoblastic leukemia patients by molecular -DNA based method [PCR-SSP, RSC4] in addition to serological method