Epidemiological Profile of Patients with Infective Endocarditis at three Tertiary Centers in Brazil from 2003 to 2017

Abstract Background Infective endocarditis (IE) is a disease with high morbimortality and an increasing incidence. With improved diagnosis and treatment, a number of epidemiological changes have been reported over time. Objectives We sought to describe the epidemiological profile, mortality predictors, and analysis of a possible microbiological transition in patients admitted to three tertiary centers in Brazil. Methods In this cross-sectional retrospective study, data from 211 patients with definite or probable IE were analyzed according to the modified Duke criteria between 2003 and 2017. The association between categorical variables was assessed using the chi-square or Fisher's exact test, and binary logistic models were built to investigate mortality. We considered p <0.05 statistically significant. Results The median age of the sample was 48 (33-59) years old, 70.6% were men, and the most prevalent pathogen was Staphylococcus spp. (19%). Mortality was 22.3%, with increasing age being the leading risk factor for death (p = 0.028). Regarding the location of the disease, native valves were the most affected site, with the aortic valve being more affected in men than women (p = 0.017). The mean number of cases of Staphylococcus spp. (τ = 0.293, p = 0.148) and Streptococcus spp. (τ = -0.078, p = 0.727) has remained stable over the years. Conclusion No trend towards reduced or increased mortality was evident between 2003 and 2017. Although Staphylococcus spp. were the most prevalent pathogen, the expected epidemiological transition could not be observed.

Global Surgery at the National Landscape: Perspectives after the XXXIV Brazilian Congress of Surgery / Cirurgia Global no Cenário Nacional: Perspectivas após o 34º Congresso Brasileiro de Cirurgia

ABSTRACT The XXXIV Brazilian Congress of Surgery included Global Surgery for the first time in its scientific program. Global Surgery is any action in research, clinical practice, and policy-making that aims to improve access and quality of care in surgical specialties. In 2015, The Lancet Commission on Global Surgery highlighted that five billion people lack safe, timely, and affordable surgical care. Even more critical, nine of ten people cannot access essential surgical care in low and middle-income countries, where a third of the worldwide population resides, and only 6% of global surgical procedures are performed. Although Brazilian researchers and institutions have been contributing to lay the movement's foundations since 2014, Global Surgery remains a barely debated subject in the country. It is urgent to expand the field and break paradigms regarding the surgeons' role in public health in Brazil. Accomplishing these standards requires a joint effort to strategically allocate resources and identify collaboration opportunities, including those from medical societies and regulatory bodies. As members of the International Student Surgical Network of Brazil - a nonprofit organization by and for students, residents, and young physicians focused on Global Surgery - we review why investing in surgery is cost-effective to strengthen health systems, reduce morbimortality, and lead to economic development. Additionally, we highlight and propose key recommendations to foster the field at the national level.

RESUMO O 34° Congresso Brasileiro de Cirurgia incluiu Cirurgia Global pela primeira vez em seu programa científico. Cirurgia Global é qualquer ação em pesquisa, prática clínica e políticas em saúde que visa melhorar o acesso e a qualidade do atendimento em especialidades cirúrgicas. Em 2015, a Comissão da The Lancet em Cirurgia Global destacou que cinco bilhões de pessoas carecem de assistência cirúrgica segura, oportuna e acessível. Ainda mais crítico, nove em cada dez pessoas não têm acesso a cuidados cirúrgicos essenciais em países de baixa e média renda, onde um terço da população mundial reside e apenas 6% dos procedimentos cirúrgicos globais são realizados. Embora pesquisadores e instituições brasileiras tenham contribuído para lançar as bases internacionais e nacionais do movimento desde 2014, a Cirurgia Global ainda é um assunto pouco debatido no país. Assim, faz-se urgente expandir essa área de conhecimento e quebrar paradigmas quanto ao papel do cirurgião na saúde pública no Brasil. Isso requer um esforço conjunto para alocar recursos de forma estratégica bem como para identificar oportunidades de colaboração, incluindo as sociedades médicas e os órgãos reguladores. Como membros da International Student Surgical Network of Brazil - organização sem fins lucrativos feita por e para estudantes, residentes e jovens médicos com foco na Cirurgia Global - revisamos por que investir em Cirurgia é uma medida custo-efetiva para fortalecer os sistemas de saúde, reduzir a morbimortalidade e promover o desenvolvimento econômico. Além disso, destacamos e propomos recomendações-chave para fomentar a Cirurgia Global a nível nacional.