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Braz. j. med. biol. res ; 34(10): 1237-1245, Oct. 2001. ilus, tab
Artículo en Inglés | LILACS | ID: lil-299848

RESUMEN

DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension of 8,123 bp of genomic sequence and encodes a transcript of 1.8 kb that is expressed in all tissues evaluated. The predicted amino acid sequence shows a high similarity to a yeast DEAD-box RNA helicase (Dbp9b) involved in ribosome biogenesis. The new helicase maps to 7p12, a region of frequent chromosome amplifications in glioblastomas involving the epidermal growth factor receptor (EGFR) gene. Nevertheless, co-amplification of DDX26 with EGFR was not detected in nine tumors analyzed


Asunto(s)
Animales , Humanos , Cromosomas Humanos Par 7 , ARN Helicasas , Secuencia de Aminoácidos , Candida , Secuencia Conservada , Drosophila , Expresión Génica , Genes erbB-1 , Glioblastoma , Datos de Secuencia Molecular , Células Tumorales Cultivadas , Levaduras
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