RESUMEN
Background: The prognosis of squamous cell carcinoma involving the oral cavity depends on various factors. The most important predictor of relapse and hence poor prognosis is the positive surgical margin of resected tissue. Therefore, it should be considered a priority while performing surgical resection
Objective: To estimate the frequency of presence of tumor cells on margins of histopathological specimens of oral squamous cell carcinoma after safe margin resection and the reoccurrence rate
Period: Two years from January 2015 to December 2017. Setting and design: This quasi experimental study was carried out at the department of oral and maxillofacial surgery, Mayo hospital, Lahore. Methodology: Fifty patients with squamous cell carcinoma of orofacial region requiring safe margin surgical resection were selected. Presence of tumour cells on margins of histopathological specimens was determined. And monthly follow up was done for six months to check the recurrence
Results: Histopathological results of margins of total 50 patient showed that 70% patient had negative margin,26 %patients had close margin and 4% patients had involved margin. Out of these patients 12% had recurrence of the disease
Conclusion: Margins are an important predictor of disease control and its recurrence
RESUMEN
Treatment of nonresectable HCC remains unsatisfactory and different therapeutic regimes have been tested. Transarterial chemoembolization [TACE] is the most promising palliative modality for unresectable HCC and determination of the survival rates of patients after TACE is important to guide clinicians for proper management of advanced HCC. So objective of our study was to determine 1 year survival rate in patients with unresectable HCC treated by TACE. Retrospective Study. This study was conducted at Shaukat Khanum Cancer Hospital and Research Centre, Lahore from July 2009 to June 2010. 90 patients with unresectable HCC who underwent TACE treatment were identified from a prospectively collected database. Patient survival from the first TACE session was calculated at 6 and 12 months duration after TACE, with Kaplan-Meier analysis. A total of 90 patients were studied. All patients underwent TACE with appropriate technical measures. The age range of patients was 34 years to 84 years. Mean age of patients was calculated to be 59.67 years and median to be 58 yrs. 59 were males and 31 were females. In all 90 patients, none died because of the complications of TACE. 3 out of these 90 patients died within 6 months of procedure, while 11 died within 1 year. So this resulted in 14 patients out of 90 [15%], who could not survive after 1 year of TACE. 76 patients remained alive with survival rate of 84.4%. TACE is an effective treatment option for advanced unresectable HCC. Our study showed that, the overall survival benefit for such patients is tremendously improved if they are managed with TACE