Effects of steroid drugs on some chemical constituents of the liver of hamsters infected with schistosoma mansoni III Androgen

A single dose of Deca-Durabolin [nandrolone decanoate] was administered intramuscularly [0.5 mg/100g body weight] to normal and Schistosoma mansoni infected hamsters. The hormone had no significant effect on the weight or water content of the liver in normal and infected hamsters. Administration of hormone was followed by a decrease of proteins in the liver of normal and infected hamsters. Hence, Decadurabolin had no anabolic effect on the liver. Also, a concomitant decrease in hepatic succinate dehydrogenase activity was observed in normal and infected hamsters. The hepatic lipids were increased in normal hamsters and decreased in infected hamsters after drug treatment. Therefore, it seems that Decadurabolin protect the liver of infected hamsters against fatty infilteration. The steroid induced a significant increase in hepatic glycogen of infected hamsters only

Effects of steroid drugs on some chemical constituents of the liver of hamsters infected with schistosoma mansoni I Oral contraceptive

The present work deals with the effect of Nordette [oral contraceptive] on some chemical constituents of the liver of normal and Schistosoma mansoni infected hamsters. Infection was found to cause an increase in the weight and water content of the liver. On the other hand, a decrease in the glycogen content and succinate dehydrogenase activity was recorded. In case of Nordette treated hamsters, the lipids content was increased in the liver of normal hamsters, while succinate dehydrogenase activity was decreased in both normal and infected animals

Effects of steroid drugs on some chemical constituents of the liver of hamsters infected with schistosoma mansoni II Glucocorticoid

Betamethasone [9 alpha-fluoro-16 beta-methyl-prednisolone] was administered orally [20 ug/100 g/day for 7 days] to normal and Schistosoma mansoni infected hamsters. The drug increased the liver weight in normal hamsters, but no such effect was seen in infected animals. A decrease in the proteins content of liver was noted in both normal and infected hamsters after Betamethasone treatment. Also, a decrease in the hepatic lipids content was evident in infected hamsters but not in normals. In normal and infected hamsters treated with Betamethasone, there was no change in hepatic contents of water, glycogen and succinate dehydrogenase activity