RESUMEN
Cyanide intoxication in mice can be antagonized by the opiate antagonist, naloxone hydrochloride alone or in combination with sodium thiosulfate. Potency ratios, derived from acute lethality values, arterial blood gases analysis and electrocardiogram tracting, were compared in groups of mice treated with sodium thiosulfate [i.p. 1 g/kg] and naloxone HCl [s.c. 3.33 mg/kg], either alone or in combination with sodium cyanide. These results indicated that naloxone HCl provided a significant protection against the lethal effects of sodium cyanide. The protective effect of sodium thiosulfate was enhanced with naloxone HCl. Naloxone HCl also provided a significant protection against the effects of sodium cyanide on arterial blood gases and on electrocardiagram, and the protective effect of sodium thiosulfate was enhanced with naloxone HCl