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1.
Korean Journal of Epidemiology ; : 59-68, 2004.
Artículo en Coreano | WPRIM | ID: wpr-729123

RESUMEN

Epidemiologic Investigation into an Outbreak of Typhoid Fever Recognized by Electronic Data Interchange in Gyeongsangbuk-do, 2003 PURPOSE: Fourteen cases of typhoid fever occurred in Gyeongsan-si, Gyeongsangbuk-do from May 22 to July 19, 2003. Especially, 6 cases were students of Y University located in Gyeongsan-si. This investigation was carried out to study the infection source and transmission of typhoid fever and to institute an effective prevention counterplan. METHODS: The authors conducted an epidemiologic survey from June 25, 2003 among the 14 cases, restaurants and employees of the whole neighborhood of Y University. Widal test was carried out for the restaurant employees and schoolmates of the 13-year-old case Miss Kim. The authors executed a pulsed field gel electrophoresis (PFGE) for Salmonella typhi cultured from 9 cases. The authors collected data about chloride and turbid levels of treated water from April to June in Gyeongsan-si water treatment plant and repair work records of waterworks pipe line in Gyeongsan-si city hall. RESULTS: All cases had used restaurants of the whole neighborhood of Y University within 2 months before the typhoid fever symptoms were developed, but the restaurant that was rarely visited by any of the patients had a case to be matched. In the results of the Widal test, 9 out of 45 of subjects (20.0%) were suspicious cases or showed a value to suggest past infection. In the results of PFGE test, there were 3 subtypes, and each subtype had a similar DNA fragments array. In all cases the patients drank tap water when they visited the restaurants. The restaurants provided drinking water from filtered tap water rather than boiled water, and all patients had drunk this water. The chlorine level of the treated water was the normal value in the Gyeongsan-si water treatment plant, but in 2 times the value was the minimum standard level. There was water pipe construction work in some regions of the whole neighborhood of Y University. The number of gastrointestinal patients in 2003 was approximately 2 times that in 2002 at the health center in Y University. CONCLUSIONS: The possibility that typhoid fever was generated in the whole neighborhood of Y University is very high. Among various possibilities, the highest possibility is the pollution of tap water intake by water leakage of a water pipe. There was no case of patient infection after strengthening of the tap water disinfection. Thorough disinfection, boiled drinking water and a periodic carrier inspection are necessary to prevent additional local occurrences of these typhoid infections.


Asunto(s)
Adolescente , Humanos , Cloro , Desinfección , ADN , Ingestión de Líquidos , Agua Potable , Electroforesis en Gel de Campo Pulsado , Estudios Epidemiológicos , Plantas , Valores de Referencia , Características de la Residencia , Restaurantes , Salmonella typhi , Fiebre Tifoidea , Agua , Purificación del Agua
2.
Korean Circulation Journal ; : 68-71, 2003.
Artículo en Coreano | WPRIM | ID: wpr-54256

RESUMEN

Neurofibromatosis type 1 (NF-1), or von Recklinhausen's disease, is an autosomal dominant disorder that primarily affects the skin, the central and peripheral nervous systems, and the skeleton. Vasculopathy, such as, aneurysm or stenosis of large vessels is a less common manifestation of NF-1, but spontaneous aortic dissection in NF-1 is very rare. We report a case of acute aortic dissection with incidental aneurysm of the right femoral artery in NF-1.


Asunto(s)
Humanos , Aneurisma , Constricción Patológica , Arteria Femoral , Neurofibromatosis , Neurofibromatosis 1 , Sistema Nervioso Periférico , Esqueleto , Piel
3.
Tuberculosis and Respiratory Diseases ; : 411-418, 2002.
Artículo en Coreano | WPRIM | ID: wpr-137759

RESUMEN

Pulmonary alveolar proteinosis(PAP) is a disorder in which an insoluble, proteinaceous material, rich in phospholipids, is deposited in the alveoli and bronchioles. The deficiency in the clearance and degradation of the i ntra-alveolar phospholipoproteinaceous material in PAP most likely represents a dysfunction of the type II pneumocytes. Although the pathogenesis and causative treatment of PAP is unclear a whole lung bronchopulmonary lavage is a relatively safe and effective treatment. Here we experienced a case of pulmonary alveolar proteinosis in a 62 year old female patient who had pulmonary tuberculosis approximately 20 years ago. She complained of aggravated dyspnea and chronic cough, and presented fine inspiratory crackles at both lung fields. diffuse ground glass opacity with some area of consolidation and smooth interlobular septal thickenings in both upper, right middle lobes, and a portion of right lower lobe. Optical microscopy of the lung tissue obtained by an open lung biopsy many granulomas containing acid-fast smear positive bacilli and diffuse homogeneous PAS-positive fluid in the alveolar space. Immunohistochemical stain showed surfactant A in the alveolar space. Antituberculosis drugs with bronchoalveolar lavage were used to treat the disease. There after she showed improvement in her symptoms and a partial improvement in the chest X-ray and HRCT findings. We present a case of PAT associated with pulmonary tuberculosis.


Asunto(s)
Femenino , Humanos , Persona de Mediana Edad , Biopsia , Bronquiolos , Lavado Broncoalveolar , Tos , Disnea , Vidrio , Granuloma , Pulmón , Microscopía , Fosfolípidos , Células Epiteliales Alveolares , Proteinosis Alveolar Pulmonar , Ruidos Respiratorios , Tórax , Tuberculosis Pulmonar
4.
Tuberculosis and Respiratory Diseases ; : 411-418, 2002.
Artículo en Coreano | WPRIM | ID: wpr-137758

RESUMEN

Pulmonary alveolar proteinosis(PAP) is a disorder in which an insoluble, proteinaceous material, rich in phospholipids, is deposited in the alveoli and bronchioles. The deficiency in the clearance and degradation of the i ntra-alveolar phospholipoproteinaceous material in PAP most likely represents a dysfunction of the type II pneumocytes. Although the pathogenesis and causative treatment of PAP is unclear a whole lung bronchopulmonary lavage is a relatively safe and effective treatment. Here we experienced a case of pulmonary alveolar proteinosis in a 62 year old female patient who had pulmonary tuberculosis approximately 20 years ago. She complained of aggravated dyspnea and chronic cough, and presented fine inspiratory crackles at both lung fields. diffuse ground glass opacity with some area of consolidation and smooth interlobular septal thickenings in both upper, right middle lobes, and a portion of right lower lobe. Optical microscopy of the lung tissue obtained by an open lung biopsy many granulomas containing acid-fast smear positive bacilli and diffuse homogeneous PAS-positive fluid in the alveolar space. Immunohistochemical stain showed surfactant A in the alveolar space. Antituberculosis drugs with bronchoalveolar lavage were used to treat the disease. There after she showed improvement in her symptoms and a partial improvement in the chest X-ray and HRCT findings. We present a case of PAT associated with pulmonary tuberculosis.


Asunto(s)
Femenino , Humanos , Persona de Mediana Edad , Biopsia , Bronquiolos , Lavado Broncoalveolar , Tos , Disnea , Vidrio , Granuloma , Pulmón , Microscopía , Fosfolípidos , Células Epiteliales Alveolares , Proteinosis Alveolar Pulmonar , Ruidos Respiratorios , Tórax , Tuberculosis Pulmonar
5.
The Journal of the Korean Rheumatism Association ; : 330-334, 2002.
Artículo en Coreano | WPRIM | ID: wpr-74233

RESUMEN

Overlap syndrome is used to describe patients who have two or more well-defined connective tissue diseases. Although a variety of overlap syndromes are now recognized, the coexistence of the progression of juvenile rheumatoid arthritis (JRA) to systemic lupus erythematosus (SLE) is uncommon. We describe a patient who had typical deforming polyarthritis, who years later developed SLE.


Asunto(s)
Humanos , Artritis , Artritis Juvenil , Enfermedades del Tejido Conjuntivo , Lupus Eritematoso Sistémico
6.
Korean Journal of Nephrology ; : 820-825, 2002.
Artículo en Coreano | WPRIM | ID: wpr-196169

RESUMEN

Membranous nephropathy (MGN) is a common cause for nephrotic syndrome in adults. Renal failure usually develops gradually in patients with MGN and rapid deterioration of renal function is a rare complication. Moreover, the development of crescentric glomerulonephritis (CGN) as a cause of acute renal failure (ARF) in patients with preexisting MGN is very rare. We report 20-year-old male patient with MGN who presented with ARF due to superimposed CGN. He had been diagnosed as idiopathic MGN and his renal function was maintained within normal range. After 13 months of conservative treatment, ARF was developed and renal biopsy was performed to differentiate the possible causes of ARF. Renal biopsy revealed diffuse crescents formation on preexisting MGN. Anti-GBM antibody and ANCA were not detected. This patient was treated with combination therapy including methylprednisolone pulse therapy followed by high dose steroid and cyclophosphamide. His renal function was improved significantly 2 weeks after treatment. In conclusion, when unexplained ARF in patient with MGN develops, prompt investigation for superimposed conditions including CGN is necessary and repeat renal biopsy should be considered.


Asunto(s)
Adulto , Humanos , Masculino , Adulto Joven , Lesión Renal Aguda , Anticuerpos Anticitoplasma de Neutrófilos , Biopsia , Ciclofosfamida , Glomerulonefritis , Glomerulonefritis Membranosa , Metilprednisolona , Síndrome Nefrótico , Valores de Referencia , Insuficiencia Renal
7.
Korean Journal of Nephrology ; : 826-830, 2002.
Artículo en Coreano | WPRIM | ID: wpr-196168

RESUMEN

Medullary cystic disease (MCD) and familial juvenile nephronophthisis are inherited diseases characterized by development of small cysts at the cortico- medullary borders of the kidneys. Both diseases consist of microscopic or gross cysts of the renal medullae associated with atrophy of nephrons, anemia, renal insufficiency, polyuria, and salt-wasting. We report a 27-year-old pregnant female patient with MCD which caused acute renal failure progressing to end stage renal disease during the second trimester. Hypertension, oliguria, preeclampsia, placenta abruptio, and disseminated intravascular coagulation were also accompanied. Radiologically, abdominal ultrasonography and computed tomogram showed many cysts confined only to the renal medullae, which are typical findings consistent with MCD. In spite of conservative therapy, her renal function deteriorated rapidly and uremic symptoms including pulmonary edema were aggravated. She was started on hemodialysis and she has received regular hemodialysis without recovery of renal function.


Asunto(s)
Adulto , Femenino , Humanos , Embarazo , Lesión Renal Aguda , Anemia , Atrofia , Coagulación Intravascular Diseminada , Hipertensión , Riñón , Fallo Renal Crónico , Nefronas , Oliguria , Placenta , Poliuria , Preeclampsia , Segundo Trimestre del Embarazo , Edema Pulmonar , Diálisis Renal , Insuficiencia Renal , Ultrasonografía
8.
Korean Journal of Perinatology ; : 185-190, 2000.
Artículo en Coreano | WPRIM | ID: wpr-187470

RESUMEN

No abstract available.


Asunto(s)
Femenino , Embarazo , Trabajo de Parto Inducido
9.
Korean Journal of Perinatology ; : 191-196, 2000.
Artículo en Coreano | WPRIM | ID: wpr-187469

RESUMEN

No abstract available.


Asunto(s)
Humanos , Lactante , Razón de Masculinidad
10.
Korean Journal of Obstetrics and Gynecology ; : 1200-1211, 1997.
Artículo en Coreano | WPRIM | ID: wpr-221868

RESUMEN

Traditionally, preeclamptic women who meet established criteria for severe disease aredelivered expeditiously. Although delivery is always appropriate thrapy for the mother, itmay not be for the fetus remote from term. The purpose of this investigation was to evaluatethe differences of pregnancy and neonatal outcome of severe preeclampsia and normalpregnancy, especially before 34 weeks gestational age, and to determine whether aggressiveor expectant management of severe preeclampsia before 34 weeks is more beneficial tomaternal and fetal outcome. A hundred and twenty consecutive pregnancies complicated bysevere preeclampsia and a hundred and twenty normal pregnancies were stuided.The results were as follows:1. The incidence of severe preeclampsia was 3.9%(130 of 3328). The 26~30 year oldage group was most common, 43%(52 patients).2. In case of study between severe preeclamptic patients and normal pregnant patient,there was no differences regarding gestational age at delivery, birth weight, cesarean sectionrate, incidence of RDS, perinatal death. The 1min/5 min Apgar scores of severe preeclampsiais significantly lower than control group(6/7 vs 7/8, p < 0.05). Neonates with SGA(small for gestational age) were found in 29% neonates of patients with severe preeclampsia,which is significantly higher than normal pregnancy group(6%, p < 0.05).3. There was no significant difference between expectant(n=10) and aggressive(n=21)management group less than 34 weeks gestation regarding the gestational age of admissionand delivery, blood pressure, proteinuria, serum creatinine, hemoglobin, hematocrit, pletelets,liver enzymes, and LDH. Only the prolongation of gestational age in the expectant managementgroup is significantly higher than in the aggressive management group(7 vs 2 days,p < 0.05).4. The neonatal and pregnancy outcome of expectant(n=10) and aggressive managementgroup(n=15) were as follow: The birth weight in the expectant management groupis lower than in the aggressive management group(1316.7+/-668.8g vs 1576.2+/-428.7 g, p < 0. 05). The incidence of SGA in the expectant management group is higher than in theaggressive management gorup(50% vs 27%, p=not significant). There was no significant differencebetween expectant and aggressive management group regarding the 1 min/ 5 minApgar score, the cesarean section rate, and the frequency of respiratory distress syndrome,cerebral hemorrhage, renal failure, sepsis, DIC of neonates.


Asunto(s)
Femenino , Humanos , Recién Nacido , Embarazo , Peso al Nacer , Presión Sanguínea , Cesárea , Creatinina , Dacarbazina , Feto , Edad Gestacional , Hematócrito , Hemorragia , Incidencia , Madres , Preeclampsia , Resultado del Embarazo , Proteinuria , Insuficiencia Renal , Sepsis
11.
Korean Journal of Gynecologic Oncology and Colposcopy ; : 270-277, 1996.
Artículo en Coreano | WPRIM | ID: wpr-206957

RESUMEN

Fifteen women with symptomatic uterine myomas, diagnosed by clinical examination and confirmed by pelvic ultrasonography, were treated with intranasal insufflation of Nafarelin acetate, 200 micrograms, twice a day, for a total treatment period of 6 months. Treatment was evaluated with respect to subjective symptoms, changes in myoma size and uterine volume, variations in blood estradiol, FSH, LH and CA 125, and side effects. The following results were obtained: 1. All patients showed a marked reduction(p<0.001) in uterine volume. Before treatment volume measured 312.3+/-24.2cm3, after 12 weeks volume was 132.4+/-40.6cm3, and after 24 weeks it was 123.6+/-48.3cm3. 2. Blood estradiol and LH levels were decreased significantly(p<0.05) after treatment. The FSH level was decreased, but not significantly. 3. Blood CA 125 levels were increased 6 cases(40.0%) before treatment. The levels were normalized in all 6 cases after treatment. 4. Symptoms of uterine myoma disappeared or decreased. 5. Minor side effects, such as hot flushes, headache, general myalgia and fatigue, and vaginal dryness were encountered frequently although none necessitating discontinuation of treatment, These data suggest that Nafarelin acetate is useful for the treatment of uterine myoma. However, appropriate indications should be selected in the treatment of uterine myoma because the possible regrowth of uterine myoma after treatment limits the use of GnRH agonist.


Asunto(s)
Femenino , Humanos , Estradiol , Fatiga , Hormona Liberadora de Gonadotropina , Cefalea , Insuflación , Leiomioma , Mialgia , Mioma , Nafarelina , Ultrasonografía
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