RESUMEN
Background: Excessive oxidative stress on fracture case can inhibit fracture healing and decrease time of bone healing. Thymoquinone, an active substance of Nigella sativa, the so-called black cumin in common, is a potent antioxidant and have been studied as an antiosteoporotic agent. Thymoquinone is expected to be the adjuvant alternative that enhance the recovery process of fracture cases by reducing oxidative stress and promotes osteoblast proliferation on callus formation.Methods: Among 32 male mice Wistar Strain divided into 2 groups, conducted tibia fracture and casted. Group 1 was the control group without supplementation of Nigella sativa while black-cummin extract were given in group 2 orally at a dose of 800 mg/kg for 14 days. On the 14th day, group 1 and 2 were sacrificed, each bone tissue was taken to measure the levels of MDA by utilizing TBARS method and calculate the number of osteoblasts under the microscope. Data analysis were done using independent t-test.Results: There are both decreased MDA levels and increased number of osteoblasts that are histologically significant to the groups administered by Nigella sativa extract containing Thymoquinone compared to the control groups (p <0.05) on day 14.Conclusions: The administration of Thymoquinone from the extract of Nigella sativa reduced oxidative stress in fractures as well as increase the number of the osteoblast and its differentiation in callus formation.
RESUMEN
The hemiarthroplasty is most commonly used after a fracture or musculoskeletal tumor of the shoulder where the blood supply to the ball portion (the humeral head) of the humerus is damaged. Since then, hemiarthoplasty has been used in many shoulder diseases including osteoarthritis, avascular necrosis, rheumatoid arthritis, cuff-tear arthropathy, and fracture sequele. Methods are authors evaluated 2 patients who had shoulder hemiarthroplasty on October 2017. The first patient is 53-year-old male, surgery due to primary bone tumor right proximal humerus suspected chondrosarcoma and the second is 72-year-old female with closed fracture dislocation of left glenohumeral joint after traffic accident. The patients followed up until 2 years and get routine medical rehabilitation on outpatients’ workup. ROM of shoulder joints which had operated evaluated 2 years post-operative. Results are First patient, active ROM extension is 20o, flexion is 10o, abduction is 30o, adduction is 20o, external rotation is 10o, internal rotation is 40o, while passive ROM extension is 150o, flexion is 30o, abduction is 110o, adduction is 40o, external rotation is 30o while internal rotation is 50o. Second patient, active ROM extension is 60o, flexion is 20o, abduction is 40o, adduction is 40o, external rotation is 20o, internal rotation is 60o, while passive ROM extension is 10o, flexion is 45o, abduction is 160o, adduction is 45o, external rotation is 30o while internal rotation is 80o. Conclusions are Careful and long-term post-operative care including Rehabilitation plays an important role in functional outcomes after Shoulder hemiarthroplasty.