Primary immuno-deficiencies in pediatrics

Introduction: There are many different types of primary immunodeficiency syndromes, with an overall prevalence of one in every 2,000 children in the United States. These syndromes are broadly classified as B-cell, T-cell, phagocytic, complement, or combined immunodeficiency disorders, mainly affecting children from a very young age

Methodology: We conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE from January 1987 to March 2017. The following search terms were used: immunodeficiency syndromes, B-cell disorder, T-cell disorder, complement disorder, phagocytic diseases, diagnosis of primary immunodeficiency, newborn screening

Aim of the work: In this study we aimed to understand the various common types of primary immunodeficiency syndromes, and also study their diagnosis and screening methods

Conclusion: Early diagnosis with the help of newborn screening and data recording can help in reducing significant mortality and morbidity of children born with such disorders. Primary health care providers and pediatricians must keep a high degree of suspicion as many times the presentation can be subtle

Infection with genital herpes virus and its treatment in relation to preterm delivery

Infection with herpes simplex is a standout amongst the most well-sexually transmitted infections. As the infection is common in women of reproductive age it may be contracted and transmitted to the fetus amid pregnancy and the new-born. Herpes simplex virus is a significant cause of neonatal infection, which could lead to death or long-term disabilities. Infrequently in the uterus, as it happens frequently during the transmission delivery. The most serious danger of transmission to the fetus and the new-born happens in case of an early maternal infection contracted in the second half of pregnancy. The danger of transmission of maternalfetal-neonatal herpes simplex could be diminished by applying a treatment with antiviral medicines or depending on a caesarean section in some particular cases. The aim of this paper is to provide recommendations on the management of herpes simplex infections in pregnancy and approaches to decrease perinatal transmission of herpes simplex virus