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1.
Indian J Exp Biol ; 2014 Sept; 52(9): 876-881
Artículo en Inglés | IMSEAR | ID: sea-153771

RESUMEN

The inflammatory bowel disease (IBD) is an idiopathic, immune mediated and chronic inflammation of the intestine. The study aimed to elucidate the ameliorative effect of methanolic extract of Dillenia indica (DIME), hexane fraction (HFDI) and chloroform fraction (CFDI) of Dillenia indica in acetic acid induced experimental colitis in mice. Macroscopic score, colon weight, colonic catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), myeloperoxidase (MPO), malondialdehyde (MDA), tumor necrosis factor (TNF-α), and histological changes were recorded after the treatment regimen of 7 days. Intra-rectal instillation of acetic acid caused enhanced macroscopic score, colon weight, colonic MPO, MDA, and TNF-α level. It caused significant decreased level of CAT, SOD and GSH. DIME (800 mg/kg), HFDI (200 mg/kg) and CFDI (200 mg/kg) treatment exhibited significant effect in lowering macroscopic score, colon weight, MPO, MDA, TNF-α levels and elevation of CAT, GSH and SOD levels. The results suggest that D. indica has ameliorating effects on experimental colitis by inhibiting the proinflammatory mediators like TNF-α production.


Asunto(s)
Ácido Acético , Animales , Colitis/inducido químicamente , Colitis/tratamiento farmacológico , Colon/efectos de los fármacos , Colon/patología , Dilleniaceae/química , Femenino , Ratones , Tamaño de los Órganos/efectos de los fármacos , Extractos Vegetales/química , Extractos Vegetales/farmacología , Sustancias Protectoras/química , Sustancias Protectoras/farmacología
2.
Indian J Exp Biol ; 2008 Jun; 46(6): 457-64
Artículo en Inglés | IMSEAR | ID: sea-62781

RESUMEN

The petroleum ether soluble fraction (SIPE) of the root extract of S. indicum was evaluated for the vasorelaxant activity using isolated rat aorta. SIPE up to 180 microg/ml concentration significantly inhibited phenylephrine- and KCl-induced contraction to the extent of 98.13 +/- 6.37 and 70.19 +/- 3.43% respectively in isolated rat aorta in a concentration dependent manner. The vasorelaxant activity was not blocked by propranolol (10 microM), atropine (1 microM) indomethacin (10 microM) and glibenclamide (10 microM). Influence of SIPE on phenylephrine-induced contractions in aortic preparations in absence of functional endothelium and on pre-incubating the tissue with L-NAME (300 microM) or methylene blue (10 microM) was also studied. SIPE at 180 microg/ml concentration could elicit partial relaxation in presence of L-NAME or methylene blue to the extent of 34.26 +/- 6.13 and 25.66 +/- 10.95% respectively. However, in absence of functional endothelium, SIPE exhibited little relaxation to the extent of 6.70 +/- 4.87%. These studies revealed that the vasorelaxant activity of SIPE was chiefly mediated through endothelium-dependent pathway.


Asunto(s)
Animales , Aorta Torácica/efectos de los fármacos , Femenino , Masculino , Fitoterapia , Extractos Vegetales/química , Raíces de Plantas , Ratas , Sesamum , Vasodilatación/efectos de los fármacos , Vasodilatadores/farmacología
3.
Indian J Exp Biol ; 2007 May; 45(5): 419-24
Artículo en Inglés | IMSEAR | ID: sea-56707

RESUMEN

The effect of chloroform soluble fraction (F-A) of twigs of Sarcostemma brevistigma on contractions induced by KCl, histamine, and acetylcholine in the isolated guinea pig ileum and taenia coli smooth muscles has been evaluated. F-A (19.5 microg/ml) significantly inhibited the contraction induced by 40 mM KCl to the extent of 87.6% in the isolated guinea pig ileum. In the isolated guinea pig ileum, F-A (64.3 and 59.2 microg/ml) significantly inhibited the contractions induced by acetylcholine and histamine to the extent of 85 and 83% respectively. In the isolated guinea pig taenia coli, F-A (65.2 microg/ml) significantly inhibited the contraction induced by 40 mM KCl to the extent of 96.0%. The inhibitory effect of F-A (40 microg/ml) on the isolated guinea pig taenia coli was reduced by Bay K 8644 (10(-6) M) to the extent of 61.6 from 73.6%. These results suggest that the F-A may exhibit smooth muscle relaxant activity by blocking the Ca2+ channels.


Asunto(s)
Acetilcolina/farmacología , Animales , Apocynaceae/química , Relación Dosis-Respuesta a Droga , Cobayas , Histamina/farmacología , Íleon/efectos de los fármacos , Masculino , Contracción Muscular/efectos de los fármacos , Músculo Liso/efectos de los fármacos , Parasimpatolíticos/farmacología , Extractos Vegetales/química , Cloruro de Potasio/farmacología , Verapamilo/farmacología
4.
Almustansiriya Journal of Pharmaceutical Sciences. 2005; 2 (2): 72-75
en Inglés | IMEMR | ID: emr-69553

RESUMEN

Zinc is the most widely studied element in term of fertility in both men and women; and zinc deficiency was reported to be associated with infertility. This prospective, randomized controlled study was conducted in the Infertility and IVF center, AL-Samarai Hospital Baghdad-Iraq, to evaluate the level of Cu/Zn ratio in the serum of women with unexplained infertility. Serum levels of copper and zinc were evaluated in twenty six women with unexplained infertility, and in twenty normal women served as control, using atomic absorption spectrophotometer. serum Zn levels were significantly lower compared to control group [6.63 mol/L +/- 0.24 VS 9.0 mol/L +/- 0.9, P= 0.01], serum Cu levels were significantly higher compared to controls [10.92 mol/L +/- 0.4 VS 7.81 mol/L +/- 0.38, P=0.01], Cu/Zn ratio was higher in infertile group [1.65 +/- 0.014 VS 0.86 +/- 0.011, P= 0.02]. From these results it was concluded that the increase in Cu/Zn ratio may have an important etiological role in the pathogenicity of unexplained infertility, and therapeutic intervention in this respect may be beneficial in the treatment of this condition


Asunto(s)
Humanos , Femenino , Infertilidad/sangre , Infertilidad/terapia , Zinc/sangre , Zinc , Cobre/sangre , Zinc/deficiencia , Espectrofotometría Atómica
5.
Indian J Exp Biol ; 2000 Aug; 38(8): 837-40
Artículo en Inglés | IMSEAR | ID: sea-57936

RESUMEN

The ethanolic extract of T. purpurea Linn. was studied for its in vitro effect on rat mast cell degranulation and erythrocyte membrane integrity in vitro. The extract in concentration of 25-200 microg/ml showed a dose-dependant inhibition of rat mast cell degranulation induded by compound 48/80 and egg albumin. T. purpurea extract was found to inhibit haemolysis of erythrocytes induced by hypotonic solution but accelerated haemolysis induced by heat at a concentration of 100 microg/ml. The studies reveal that the ethanolic extract of T. purpurea may inhibit degranulation of mast cells by a mechanism other than membrane stabilization.


Asunto(s)
Animales , Degranulación de la Célula/efectos de los fármacos , Membrana Eritrocítica/efectos de los fármacos , Etanol/química , Fabaceae/química , Humanos , Mastocitos/efectos de los fármacos , Extractos Vegetales/farmacología , Ratas , Ratas Wistar
6.
Indian J Exp Biol ; 1999 Mar; 37(3): 258-61
Artículo en Inglés | IMSEAR | ID: sea-55997

RESUMEN

Volatile oil of C. deodara, administered orally at the doses of 50, 100 and 200 mg/kg body weight, significantly inhibited the pedal edema induced by compound 48/80 in rats. The oil significantly inhibited compound 48/80 induced degranulation of isolated rat peritoneal mast cells at concentrations ranging from 25-200 micrograms/ml. C. deodara wood oil also significantly inhibited the enzyme lipoxygenase at a concentration of 200 micrograms/ml. Thus, the anti-inflammatory activity of C. deodara wood oil could be attributed to its mast cell stabilizing activity and the inhibition of leukotriene synthesis.


Asunto(s)
Animales , Antiinflamatorios no Esteroideos/administración & dosificación , Degranulación de la Célula/efectos de los fármacos , Edema/inducido químicamente , Inhibidores de la Lipooxigenasa/administración & dosificación , Masculino , Mastocitos/efectos de los fármacos , Aceites de Plantas/administración & dosificación , Ratas , Ratas Wistar , Árboles , p-Metoxi-N-metilfenetilamina/toxicidad
8.
Indian J Exp Biol ; 1997 May; 35(5): 466-9
Artículo en Inglés | IMSEAR | ID: sea-60709

RESUMEN

Recent reports have indicated the effectiveness of furosemide in inhibiting responses to inhaled allergen and in treating allergic conjunctivitis. In the present study furosemide was tested for its antiallergic potential using compound 48/80 induced paw edema and in vitro mast cell degranulation. Furosemide was found to significantly inhibit compound 48/80 paw edema and compound 48/80 induced histamine release. Furosemide was also found to inhibit histamine release during passive peritoneal anaphylaxis in rats. The results suggest that furosemide may be inhibiting the release of mediators of anaphylaxis from the mast cells.


Asunto(s)
Animales , Antialérgicos/farmacología , Diuréticos/farmacología , Furosemida/farmacología , Masculino , Ratas , Ratas Wistar
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