RESUMEN
Se descrevem 3 gestantes com a doença de Chagas aguda. Duas gestantes infetadas no 3º trimestre de gestação não tiveram crianças infetadas. O 3º filho, doquella madre foi infetada no 1º trimestre, nasceu com doença de Chagas congénita. Estes resultados inducem a investigação sobre os fatores de riscos da transmição e sobre as desições médicas na conducção dos casos de gestantes com a doença de Chagas aguda.
Asunto(s)
Adolescente , Adulto , Femenino , Humanos , Recién Nacido , Masculino , Embarazo , Enfermedad de Chagas/transmisión , Transmisión Vertical de Enfermedad Infecciosa , Complicaciones Parasitarias del Embarazo , Enfermedad Aguda , Enfermedad de Chagas/congénito , Nitroimidazoles/uso terapéutico , Primer Trimestre del Embarazo , Tercer Trimestre del Embarazo , Complicaciones Parasitarias del Embarazo/parasitología , Factores de Riesgo , Tripanocidas/uso terapéuticoRESUMEN
The Kinetic properties of plasma placental alkaline phosphatase patients with Chagas' disease were studied. When Cl2 Mg was used as activator the same increase of activity (17-20 per cent) was found in the chagasic and non chagasic groups. The enzyme was not inhibited by F-ion in any of the groups. No significant differences were detected between the two groups (chagasic and non chagasic) when the enzyme was treated with inhibitors such as EDTA and L-phenylamine. However, when the CN- ion was used, the enzyme of the normal pregnant women followed a Michaelian curve, whereas in the chagasic group a sigmoideal plot was observed. Thus, the Hill coefficient was 1.1 for the normal group and over 1.5 for the chagasic.