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Introduction: Coronary artery disease (CAD) is the most common causes of mortality and morbidity in both developed and developing countries in all age groups of both genders which contribute to the biggest economic burden. Various modifiable and non modifiable risk factors contribute to the development of CAD. Our aim of the study was to determine the role of non HDL level as an individual risk factor in coronary artery disease. Material and methods: observational study done in all patients admitted with diagnosis suggestive of coronary artery disease (STEMI, NSTEMI, Unstable angina, Stable angina etc) with age more than 18 years both men and women were included in the study. Patients with previous diagnosis of dyslipidemia, patients who are on statins and other lipid lowering agent, malignancy and less than 18 years were excluded from the study. Age and sex matched control group who have been admitted to the institution with other diagnosis who were accepting to participate in the study. Non HDL –C = TOTAL CHOLESTROL – HDL-C this is the conventional formula used to calculate non HDL-C. Results: In our study the role played by the risk factors non HDL-C could be playing a greater role in causation of CAD. In the present study mean non HDL-C concentrations of study group was 138.41 ± 51.25 and control group was 116.16 ± 35.89 respectively. Conclusion: In the present study done in rural population it was found non HDL-C and LDL-C was statically significantly increased in patients admitted with CAD
RESUMEN
Objectives: Subclinical hypothyroidism (SCH) is a common disorder that is characterized by elevated thyroid-stimulating hormone levels in conjunction with free thyroxine concentrations within the normal reference range. Thyroid hormones are known to affect the heart and vasculature and, as a result, the impact of SCH on heart failure. Strong evidence points to a link between SCH and HF risk factors such as alterations in blood pressure, lipid levels, and atherosclerosis. Additionally, accumulating evidence indicates that SCH is associated with metabolic syndrome and heart failure. The present review proposes that SCH may be a potentially modifiable risk factor of heart failure and mortality. Methods: This is an observational study to determine the incidence of subclinical hypothyroidism in patients with heart failure and the cardiovascular risk profile among patients in a 750 bedded tertiary health care centre in south India, over a period from June 2018 to November 2018. Results: In our present study it was noticed that most of the patients were in the age group above 51-60 yrs (45.45 %). Our study data suggest that subclinical hypothyroidism with a TSH ≥10.0 mIU/L represents a potentially modifiable risk factor for HF in older adults but not subclinical hypothyroidism with moderate TSH levels (TSH 4.5 to 9.9 mIU/L) and subclinical hyperthyroidism. Conclusion: Subclinical hypothyroidism are more prone to associated with heart failure as an asymptomatic which is essential to be identified and treated for a better outcome as its association is proven statistically in our study.