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Indian J Med Microbiol ; 2007 Jul; 25(3): 203-8
Artículo en Inglés | IMSEAR | ID: sea-53886

RESUMEN

PURPOSE: To evaluate the spectrum of activity of three beta-lactamase inhibitors such as amoxicillin/ clavulanic acid, ticarcillin/ clavulanic acid and piperacillin/ tazobactam in comparison to cephalosporins against gram negative bacilli. METHODS: Gram-negative bacilli isolated from the clinical specimens received in the laboratory were included in the study. Using the API system (bioMiotarieux) during a one-year period, a total of 1,252 Enterobacteriaceae and 385 non-fermenters were evaluated. RESULTS: The percentage resistance of the Enterobacteriaceae isolates was 82.92% to amoxicillin/ clavulanic acid, 58.22% to ticarcillin/clavulanic acid and 22.44% to piperacillin/tazobactam respectively. Pseudomonas aeruginosa showed resistance of 96% to ticarcillin/ clavulanic acid and 61% to piperacillin/ tazobactam and Acinetobacter baumannii showed 49% resistance to ticarcillin/ clavulanic acid and 77% resistance to piperacillin/ tazobactam respectively. The isolates exhibited high resistance to all the generations of cephalosporins and the other groups of antibiotics except carbapenems. CONCLUSIONS: Piperacillin/tazobactam was found to be the most active combination of the three against Enterobacteriaceae and Pseudomonas spp. and ticarcillin/clavulanic acid against Acinetobacter spp. and Stenotrophomonas maltophilia.


Asunto(s)
Acinetobacter/efectos de los fármacos , Amoxicilina/farmacología , Ácido Clavulánico/farmacología , Enterobacteriaceae/efectos de los fármacos , Inhibidores Enzimáticos/farmacología , Bacterias Gramnegativas/efectos de los fármacos , Pruebas de Sensibilidad Microbiana/métodos , Ácido Penicilánico/análogos & derivados , Piperacilina/farmacología , Pseudomonas/efectos de los fármacos , Stenotrophomonas/efectos de los fármacos , Ticarcilina/farmacología , Resistencia betalactámica , beta-Lactamasas/antagonistas & inhibidores , beta-Lactamas/farmacología
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