Síndrome antifosfolipídica e morbidade gestacional / Antiphospholipid syndrome and morbidity gestation

A síndrome antifosfolipídica (SAF) é a mais comum das trombofilias adquiridas do adulto jovem. Ocorre de forma primária ou em associação com doenças do conjuntivo, particularmente o lupus eritematoso. A ocorrência de eventos obstrétricos em pacientes com SAF é assunto de grande interesse entre profissionais da área da Reumatologia e Gineco-Obstetricia. Abordamos, neste artigo, aspectos conceituais da SAF e os eventos obstétricos (abortamentos recorrentes, pré-eclâmpsia) relacionados à presença dos anticorpos contra fosfolípides.

Dectecçäo de doença arterial coronariana baseada no índice de calcificaçäo obtido pela tomografia computadorizada heliocoidal / Detection of coronary artery disease based on the calcification index obtained by helical computed tomography

OBJECTIVE: To assess the relation between coronary artery disease and the calcification index on helical computed tomography. METHOD: We studied 22 patients (ages ranging from 40 to 70 years) who underwent coronary angiography because of chest pain suggestive of angina pectoris. Findings on coronary angiography were classified as follows: significant obstructive disease (stenosis > or = 50 percent), nonobstructive disease (stenosis <50 percent), and no disease. With no previous knowledge of the results of the coronary angiography and within 7 days, helical computed tomography of the chest was performed. Then, data of the coronary angiography were correlated with the calcification index obtained by helical computed tomography. RESULTS: The sensitivity of helical computed tomography to the presence of significant obstructive lesions on coronary angiography was 87.5 percent, specificity was 100 percent, and negative and positive predictive values were 75 percent and 100 percent, respectively. The mean calcification index was greater in patients with severe coronary lesions, mainly when involvement of 2 or 3 vessels occurred, than that in patients with no coronary artery disease or with nonobstructive coronary artery lesions (p<0.05). CONCLUSION: Helical computed tomography is an effective method for detecting and quantifying coronary artery calcification, and it has proved to be sensitive to and specific for the noninvasive diagnosis of coronary artery stenosis

Revisäo de aspectos relevantes da Síndrome de West / West Syndrome: an up-date

Trabalho de revisäo bilbiográfica sobre a Síndrome de West, apontando aspectos relevantes quanto a sua conceituaçäo, epidemiologia, classificaçäo, etiopatogenia, quadro clínico, diagnóstico diferencial, tratamento e prognóstico...