HIV-1 protease inhibitor nelfinavir decreases insulin secretion from rat insulinoma INS-1 cells / 中华内分泌代谢杂志

Rat INS-1 cells treated with HIV-1 protease inhibitor Nelfinavir for 48 h showed that both basal and glucose-stimulated insulin secretion decreased, the latter was more marked, suggesting that long-term treatment with Nelfinavir may impair ?-cell function.