RESUMEN
1. This review desribes the role of vascular endothelium in the response induced by different vasoactive agentes. 2. The interaction between endothelium, vascular smooth muscle and platelets is discussed. 3. The hormone control as well as pmhysicochemical alterations that interfere with some endothelium-dependent vascular responses are described
Asunto(s)
Conejos , Ratas , Animales , Agregación Plaquetaria/fisiología , Endotelio Vascular/fisiología , Vasodilatación/fisiología , Acetilcolina/farmacología , Músculo Liso Vascular , Norepinefrina/farmacologíaRESUMEN
The responses to noradrenaline (NA) and acetylcholine (ACh) of aortae and microvessels were cocmpared in control and DOCA-salt hypertensive rats. Macro - and microvessels from hypertensive rats showed an increased response to NA and a decreased response to ACh (an endothelium-dependent vasodilator). Unlike ACh, sodium nitroprusside (an endothelium-independent agent), was equally effective in evoking a vasodilator response from aortae and microvessels of hypertensive rats. These data suggest that the impaired response to ACh and the increased response to NA in DOCA-salt hypertension may result from an alteration of endothelial cell function