Development of the Korean-version of Female Sexual Function Index (FSFI) / 대한남성과학회지

PURPOSE: To develop a Korean version of FSFI for measuring the female sexual dysfunction and to verify both reliability and validity of the Korean version. MATERIALS AND METHODS: The FSFI English version was translated and back-translated with modification. Data from 116 married women residing in Gwangju city were collected through a questionnaire survey. The first and second surveys were conducted at two weeks interval for test-retest reliability. Content validity, constructvalidity, internal consistency reliability, and test-retest reliability of the FSFI Korean version were evaluated. RESULTS: Through Korean language localization of the English-version questionnaire, translations from English MATERIALS, content validity, preliminary survey and specialist panel discussions, the 19-section Korean-version questionnaire was completed. As a result of factor analysis by designating five as the number of its extracted factor, it is extracted five factors (six domains) as 'desire & arousal', 'lubrication', 'orgasm', 'satisfaction' and 'pain'. The total variance explained was 81.7%. The Cronbach's alpha coefficient for internal consistency was 0.96 and test-retest reliability was r=0.973 (p<0.001). CONCLUSIONS: The Korean version of FSFI is thought to have reliability and validity that may be used for Korean women subjects.

Effects of calcium channel blockers on porcine cardiac and coronary arterial function in ischemia-reperfusion

This study was designed to investigate effects of calcium antagonists on endothelial and neuronal dysfunction of right coronary artery (RCA) induced by ischemia- reperfusion in anesthetized, open-chest pigs. After reperfusion, pigs were sacrificed and the RCA was rapidly dissected for in vitro experiments. Experimental groups were divided into 4 groups: control (C-RCA), ischemia-reperfusion only (I-RCA), verapamil infusion (VI-RCA) and nifedipine infusion (NI-RCA) group, respectively. The ischemia did not affect hemodynamics, mean arterial pressure, heart rate, LVdP/dtmax, and decreased RCA flow. Arterial pressure and heart rate during ischemia-reperfusion were decreased in VI-RCA and NI-RCA, and RCA flow during reperfusion was increased in NI-RCA. 5-Hydroxytryptamine (5-HT) produced concentration-dependent contractions in C-RCA. The 5-HT-induced contractions were potentiated in I-RCA and VI-RCA, but not in NI-RCA. Endothelium-dependent relaxation by calcium ionophore A23187 was inhibited in I-RCA and VI-RCA, and recovered in NI-RCA. Cyclic GMP contents were decreased in I-RCA group alone. Electrical field stimulation in C-RCA produced transient and frequency-dependent contractions and at 50 Hz caused biphasic contractions. The transient contractions were not affected by pretreatment with phentolamine and atropine, but the biphasic contraction was altered by the pretreatment. Both contractions were inhibited in I-RCA, and were partially recovered in VI-RCA and NI-RCA. Ischemia-reperfusion of RCA in pigs causes endothelial and neuronal dysfunctions, and calcium antagonists partially prevent both.