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1.
Journal of Korean Medical Science ; : 1405-1410, 2012.
Artículo en Inglés | WPRIM | ID: wpr-128860

RESUMEN

This study was conducted to determine if nasal salmon calcitonin has additional beneficial effects on clinical symptoms, serum NO, IL-1beta, matrix metalloproteinase 3, urinary C-terminal telopeptide type II collagen (CTX-II) levels and MRI findings in knee osteoarthritis (OA) when used concomitantly with exercise therapy. Fifty female patients with knee OA were randomized into two groups. The first group (n = 30) received 200 IU/day nasal salmon calcitonin and a home exercise program; the second group (n = 20) received a home exercise program for 6 months. Compared with baseline,while significant improvements were observed in visual analogue scale (VAS), WOMAC pain, physical function scores, 20-m walking time (P < 0.001) and WOMAC stiffness score (P = 0.041) in the first group, walking and resting VAS, and WOMAC physical function scores were improved (P = 0.029) in the second group after treatment. Significantly increased levels of serum NO and urinary CTX-II (P < 0.001) and significant improvements in the area of medial femoral condyle (P < 0.05) were noted only in the first group. There were significant differences in VAS activation values (P = 0.032) and NO levels (P < 0.001) in the favor of the first group. In conclusion, nasal salmon calcitonin may have possible chondroprotective effects besides its known effects on symptoms in patients with knee OA.


Asunto(s)
Anciano , Femenino , Humanos , Persona de Mediana Edad , Conservadores de la Densidad Ósea/uso terapéutico , Calcitonina/uso terapéutico , Colágeno Tipo II/orina , Terapia por Ejercicio , Interleucina-1beta/sangre , Imagen por Resonancia Magnética , Metaloproteinasa 3 de la Matriz/sangre , Óxido Nítrico/sangre , Osteoartritis de la Rodilla/tratamiento farmacológico , Fragmentos de Péptidos/orina , Terapia Respiratoria , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Caminata
2.
Journal of Korean Medical Science ; : 1405-1410, 2012.
Artículo en Inglés | WPRIM | ID: wpr-128845

RESUMEN

This study was conducted to determine if nasal salmon calcitonin has additional beneficial effects on clinical symptoms, serum NO, IL-1beta, matrix metalloproteinase 3, urinary C-terminal telopeptide type II collagen (CTX-II) levels and MRI findings in knee osteoarthritis (OA) when used concomitantly with exercise therapy. Fifty female patients with knee OA were randomized into two groups. The first group (n = 30) received 200 IU/day nasal salmon calcitonin and a home exercise program; the second group (n = 20) received a home exercise program for 6 months. Compared with baseline,while significant improvements were observed in visual analogue scale (VAS), WOMAC pain, physical function scores, 20-m walking time (P < 0.001) and WOMAC stiffness score (P = 0.041) in the first group, walking and resting VAS, and WOMAC physical function scores were improved (P = 0.029) in the second group after treatment. Significantly increased levels of serum NO and urinary CTX-II (P < 0.001) and significant improvements in the area of medial femoral condyle (P < 0.05) were noted only in the first group. There were significant differences in VAS activation values (P = 0.032) and NO levels (P < 0.001) in the favor of the first group. In conclusion, nasal salmon calcitonin may have possible chondroprotective effects besides its known effects on symptoms in patients with knee OA.


Asunto(s)
Anciano , Femenino , Humanos , Persona de Mediana Edad , Conservadores de la Densidad Ósea/uso terapéutico , Calcitonina/uso terapéutico , Colágeno Tipo II/orina , Terapia por Ejercicio , Interleucina-1beta/sangre , Imagen por Resonancia Magnética , Metaloproteinasa 3 de la Matriz/sangre , Óxido Nítrico/sangre , Osteoartritis de la Rodilla/tratamiento farmacológico , Fragmentos de Péptidos/orina , Terapia Respiratoria , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Caminata
3.
Pakistan Journal of Medical Sciences. 2009; 25 (3): 484-489
en Inglés | IMEMR | ID: emr-94010

RESUMEN

To determine the gender differences between in terms of the method and reason of suicide. The suicidal proportions in seven regions of Turkey by sexes were compared according to three different age groups. The data were evaluated by Loglinear analysis. Suicide rates were higher in women in the region East Anatolia [P<0.01]. It was found that suicide by hanging was the most commonly used method in all the regions [P<0.001]. Committing suicide by hanging [P<0.01] and using firearms [P<0.001] were higher in men, whereas, committing suicide by taking chemical was higher in women [P<0.001]. Gender differences in suicidal behavior in this study clearly merit further research to generate information that can guide clinical practice and prevention strategies


Asunto(s)
Humanos , Masculino , Femenino , Identidad de Género , Factores de Riesgo
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